Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys

Auriel A. Willette; Catherine Gallagher; Barbara B. Bendlin; Donald G. McLaren; Erik K. Kastman; Elisa Canu; Kris J. Kosmatka; Aaron S. Field; Andrew L. Alexander; Ricki J. Colman; Mary Lou L Voytko; Richard H. Weindruch; Christopher L. Coe; Sterling C. Johnson

doi:10.1016/j.neurobiolaging.2010.06.003

Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys

Auriel A. Willette, Catherine Gallagher, Barbara B. Bendlin, Donald G. McLaren, Erik K. Kastman, Elisa Canu, Kris J. Kosmatka, Aaron S. Field, Andrew L. Alexander, Ricki J. Colman, Mary Lou L Voytko, Richard H. Weindruch, Christopher L. Coe, Sterling C. Johnson

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Higher serum homocysteine (Hcy) levels in humans are associated with vascular pathology and greater risk for dementia, as well as lower global and regional volumes in frontal lobe and hippocampus. Calorie restriction (CR) in rhesus monkeys (Macaca mulatta) may confer neural protection against age- or Hcy-related vascular pathology. Hcy was collected proximal to a magnetic resonance imaging (MRI) acquisition in aged rhesus monkeys and regressed against volumetric and diffusion tensor imaging indexes using voxel-wise analyses. Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum. CR did not influence Hcy levels. However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys. Similar group differences were also seen across modalities in the splenium of the corpus callosum, prefrontal cortices, hippocampus, and somatosensory areas. The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health.

Original language	English
Pages (from-to)	670-680
Number of pages	11
Journal	Neurobiology of Aging
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2010.06.003
Publication status	Published - Apr 2012

Keywords

Aging
Caloric restriction
Diffusion tensor imaging
Homocysteine
Neural atrophy
Primate
Rhesus monkey
Voxel-based morphometry

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

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Willette, A. A., Gallagher, C., Bendlin, B. B., McLaren, D. G., Kastman, E. K., Canu, E., Kosmatka, K. J., Field, A. S., Alexander, A. L., Colman, R. J., Voytko, M. L. L., Weindruch, R. H., Coe, C. L., & Johnson, S. C. (2012). Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. Neurobiology of Aging, 33(4), 670-680. https://doi.org/10.1016/j.neurobiolaging.2010.06.003

Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. / Willette, Auriel A.; Gallagher, Catherine; Bendlin, Barbara B.; McLaren, Donald G.; Kastman, Erik K.; Canu, Elisa; Kosmatka, Kris J.; Field, Aaron S.; Alexander, Andrew L.; Colman, Ricki J.; Voytko, Mary Lou L; Weindruch, Richard H.; Coe, Christopher L.; Johnson, Sterling C.

In: Neurobiology of Aging, Vol. 33, No. 4, 04.2012, p. 670-680.

Research output: Contribution to journal › Article

Willette, AA, Gallagher, C, Bendlin, BB, McLaren, DG, Kastman, EK, Canu, E, Kosmatka, KJ, Field, AS, Alexander, AL, Colman, RJ, Voytko, MLL, Weindruch, RH, Coe, CL & Johnson, SC 2012, 'Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys', Neurobiology of Aging, vol. 33, no. 4, pp. 670-680. https://doi.org/10.1016/j.neurobiolaging.2010.06.003

Willette, Auriel A. ; Gallagher, Catherine ; Bendlin, Barbara B. ; McLaren, Donald G. ; Kastman, Erik K. ; Canu, Elisa ; Kosmatka, Kris J. ; Field, Aaron S. ; Alexander, Andrew L. ; Colman, Ricki J. ; Voytko, Mary Lou L ; Weindruch, Richard H. ; Coe, Christopher L. ; Johnson, Sterling C. / Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 4. pp. 670-680.

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abstract = "Higher serum homocysteine (Hcy) levels in humans are associated with vascular pathology and greater risk for dementia, as well as lower global and regional volumes in frontal lobe and hippocampus. Calorie restriction (CR) in rhesus monkeys (Macaca mulatta) may confer neural protection against age- or Hcy-related vascular pathology. Hcy was collected proximal to a magnetic resonance imaging (MRI) acquisition in aged rhesus monkeys and regressed against volumetric and diffusion tensor imaging indexes using voxel-wise analyses. Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum. CR did not influence Hcy levels. However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys. Similar group differences were also seen across modalities in the splenium of the corpus callosum, prefrontal cortices, hippocampus, and somatosensory areas. The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health.",

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