Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment

Gianfranco Spalletta, Luca Cravello, Walter Gianni, Federica Piras, Mariangela Iorio, Claudia Cacciari, Anna Rosa Casini, Chiara Chiapponi, Giuseppe Sancesario, Claudia Fratangeli, Maria Donata Orfei, Carlo Caltagirone, Fabrizio Piras

Research output: Contribution to journalArticlepeer-review


Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.

Original languageEnglish
Pages (from-to)807-816
Number of pages10
JournalJournal of Alzheimer's Disease
Issue number3
Publication statusPublished - Feb 2 2016


  • Amnestic mild cognitive impairment
  • episodic memory
  • hippocampus
  • homotaurine
  • structural magnetic resonance imaging
  • tramiprosate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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