TY - JOUR
T1 - Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment
AU - Spalletta, Gianfranco
AU - Cravello, Luca
AU - Gianni, Walter
AU - Piras, Federica
AU - Iorio, Mariangela
AU - Cacciari, Claudia
AU - Casini, Anna Rosa
AU - Chiapponi, Chiara
AU - Sancesario, Giuseppe
AU - Fratangeli, Claudia
AU - Orfei, Maria Donata
AU - Caltagirone, Carlo
AU - Piras, Fabrizio
PY - 2016/2/2
Y1 - 2016/2/2
N2 - Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.
AB - Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.
KW - Amnestic mild cognitive impairment
KW - episodic memory
KW - hippocampus
KW - homotaurine
KW - structural magnetic resonance imaging
KW - tramiprosate
UR - http://www.scopus.com/inward/record.url?scp=84957894997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957894997&partnerID=8YFLogxK
U2 - 10.3233/JAD-150484
DO - 10.3233/JAD-150484
M3 - Article
AN - SCOPUS:84957894997
VL - 50
SP - 807
EP - 816
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -