Homotoxicological remedies versus desmopressin versus placebo in the treatment of enuresis: A randomised, double-blind, controlled trial

Pietro Ferrara, Giuseppina Marrone, Valentina Emmanuele, Alessandro Nicoletti, Antonio Mastrangelo, Eloisa Tiberi, Antonio Ruggiero, Alfonso Fasano, Fabrizia Paolini Paoletti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this trial was to compare the safety and efficacy of homotoxicological remedies versus placebo and versus desmopressin (dDAVP) in the treatment of monosymptomatic nocturnal enuresis (MNE). We conducted a randomised, double-blind, double-dummy, controlled trial in which 151 children with MNE were randomly assigned to receive oral homotoxicological remedies (n=50), dDAVP (n=50) or placebo (n=51). The primary outcomes were: the reduction of wet nights per week after 3 months of therapy; the evaluation of the numbers and percentages of non-responders and responders; the number of children relapsing after initial response and the number of children attaining 14 consecutive dry nights during the treatment. The secondary outcome was the detection of adverse effects. Baseline clinical characteristics were similar in the three groups of patients. After the 3 months of therapy there was a significant difference between the three groups (P

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalPediatric Nephrology
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Desmopressin
  • Enuresis
  • Homotoxicology
  • Treatment

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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