Homovanillic acid and 5-hydroxyindolacetic acid modifications in csf of patients with stroke and multi-infarct dementia

S. Smirne, M. Franceschi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Thirty four patients who had complete ischemic stroke confirmed by neurologic examination, were divided into three groups according to the time elapsed between the first signs of stroke and lumbar puncture: Group A, 22-47 h; group B, 48-71 h; group C, 72-96 h. Nineteen patients with multi-infarct dementia (MID) assessed by neurologic and neurophysiologic examinations were also studied. The severity of the neurological deficit was assessed by the Norris rating scale. Nine age-matched subjects without neurologic disease served as controls. Levels of homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were determined in lumbar CSF by a fluorimetric method after separation on Sephadex G-10 columns. HVA levels decreased as the length of time after stroke increased and were lower than controls in MID, while 5-HIAA levels were low in group B and MID. Our results in stroke can be interpreted as showing they are the consequence of dopamine and serotonin global depletion in the early phases of brain ischemia. In MID, the CSF changes might reflect not only tissue loss secondary to multiple infarcts but also the persistence of a state of diffuse ischemia.

Original languageEnglish
Pages (from-to)1003-1006
Number of pages4
JournalStroke
Volume16
Issue number6
Publication statusPublished - 1985

Fingerprint

Multi-Infarct Dementia
Homovanillic Acid
Stroke
Acids
Neurologic Examination
Spinal Puncture
Nervous System Diseases
Brain Ischemia
Dopamine
Serotonin
Ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

Cite this

Homovanillic acid and 5-hydroxyindolacetic acid modifications in csf of patients with stroke and multi-infarct dementia. / Smirne, S.; Franceschi, M.

In: Stroke, Vol. 16, No. 6, 1985, p. 1003-1006.

Research output: Contribution to journalArticle

@article{53b595efce644d0e9bd1922bb83d3b3f,
title = "Homovanillic acid and 5-hydroxyindolacetic acid modifications in csf of patients with stroke and multi-infarct dementia",
abstract = "Thirty four patients who had complete ischemic stroke confirmed by neurologic examination, were divided into three groups according to the time elapsed between the first signs of stroke and lumbar puncture: Group A, 22-47 h; group B, 48-71 h; group C, 72-96 h. Nineteen patients with multi-infarct dementia (MID) assessed by neurologic and neurophysiologic examinations were also studied. The severity of the neurological deficit was assessed by the Norris rating scale. Nine age-matched subjects without neurologic disease served as controls. Levels of homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were determined in lumbar CSF by a fluorimetric method after separation on Sephadex G-10 columns. HVA levels decreased as the length of time after stroke increased and were lower than controls in MID, while 5-HIAA levels were low in group B and MID. Our results in stroke can be interpreted as showing they are the consequence of dopamine and serotonin global depletion in the early phases of brain ischemia. In MID, the CSF changes might reflect not only tissue loss secondary to multiple infarcts but also the persistence of a state of diffuse ischemia.",
author = "S. Smirne and M. Franceschi",
year = "1985",
language = "English",
volume = "16",
pages = "1003--1006",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Homovanillic acid and 5-hydroxyindolacetic acid modifications in csf of patients with stroke and multi-infarct dementia

AU - Smirne, S.

AU - Franceschi, M.

PY - 1985

Y1 - 1985

N2 - Thirty four patients who had complete ischemic stroke confirmed by neurologic examination, were divided into three groups according to the time elapsed between the first signs of stroke and lumbar puncture: Group A, 22-47 h; group B, 48-71 h; group C, 72-96 h. Nineteen patients with multi-infarct dementia (MID) assessed by neurologic and neurophysiologic examinations were also studied. The severity of the neurological deficit was assessed by the Norris rating scale. Nine age-matched subjects without neurologic disease served as controls. Levels of homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were determined in lumbar CSF by a fluorimetric method after separation on Sephadex G-10 columns. HVA levels decreased as the length of time after stroke increased and were lower than controls in MID, while 5-HIAA levels were low in group B and MID. Our results in stroke can be interpreted as showing they are the consequence of dopamine and serotonin global depletion in the early phases of brain ischemia. In MID, the CSF changes might reflect not only tissue loss secondary to multiple infarcts but also the persistence of a state of diffuse ischemia.

AB - Thirty four patients who had complete ischemic stroke confirmed by neurologic examination, were divided into three groups according to the time elapsed between the first signs of stroke and lumbar puncture: Group A, 22-47 h; group B, 48-71 h; group C, 72-96 h. Nineteen patients with multi-infarct dementia (MID) assessed by neurologic and neurophysiologic examinations were also studied. The severity of the neurological deficit was assessed by the Norris rating scale. Nine age-matched subjects without neurologic disease served as controls. Levels of homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were determined in lumbar CSF by a fluorimetric method after separation on Sephadex G-10 columns. HVA levels decreased as the length of time after stroke increased and were lower than controls in MID, while 5-HIAA levels were low in group B and MID. Our results in stroke can be interpreted as showing they are the consequence of dopamine and serotonin global depletion in the early phases of brain ischemia. In MID, the CSF changes might reflect not only tissue loss secondary to multiple infarcts but also the persistence of a state of diffuse ischemia.

UR - http://www.scopus.com/inward/record.url?scp=0022377178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022377178&partnerID=8YFLogxK

M3 - Article

C2 - 2418548

AN - SCOPUS:0022377178

VL - 16

SP - 1003

EP - 1006

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 6

ER -