Abstract
HVA and 5-HIAA levels have been assayed by fluorimetric method in medulla oblongata, griseum centralis pontis, substantia nigra, red nucleus, lamina quadrigemina, caudate nucleus, and lenticular nucleus of 21 patients deceased from non-neurological diseases. Levels of both acids were not affected by varying necropsy intervals, but HVA levels decreased with increasing age. Regardless of age, patients who deceased after prolonged coma showed increased 5-HIAA levels in all brain stem areas, especially in medulla oblongata. Such an increase was strikingly high in patients with hepatic coma but less pronounced in diabetic coma. HVA levels were increased in medulla oblongata of patients with hepatic coma, in all brain stem areas after diabetic coma, and were decreased in substantia nigra of comatose patients of various etiologies. L-dopa therapy induced a remarkable HVA increase and did not affect 5-HIAA levels in all areas of patients with hepatic coma.
| Original language | English |
|---|---|
| Pages (from-to) | 487-500 |
| Number of pages | 14 |
| Journal | Acta Neurologica |
| Volume | 33 |
| Issue number | 6 |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Homovanillic acid and 5-hydroxyindoleacetic acid in human brain areas at autopsy. Effect of pre-death conditions with special attention to the state of consciousness and metabolic diseases. / Livrea, P.; Di Reda, N.; De Blasi, A.; Bertolino, A.
In: Acta Neurologica, Vol. 33, No. 6, 1978, p. 487-500.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Homovanillic acid and 5-hydroxyindoleacetic acid in human brain areas at autopsy. Effect of pre-death conditions with special attention to the state of consciousness and metabolic diseases
AU - Livrea, P.
AU - Di Reda, N.
AU - De Blasi, A.
AU - Bertolino, A.
PY - 1978
Y1 - 1978
N2 - HVA and 5-HIAA levels have been assayed by fluorimetric method in medulla oblongata, griseum centralis pontis, substantia nigra, red nucleus, lamina quadrigemina, caudate nucleus, and lenticular nucleus of 21 patients deceased from non-neurological diseases. Levels of both acids were not affected by varying necropsy intervals, but HVA levels decreased with increasing age. Regardless of age, patients who deceased after prolonged coma showed increased 5-HIAA levels in all brain stem areas, especially in medulla oblongata. Such an increase was strikingly high in patients with hepatic coma but less pronounced in diabetic coma. HVA levels were increased in medulla oblongata of patients with hepatic coma, in all brain stem areas after diabetic coma, and were decreased in substantia nigra of comatose patients of various etiologies. L-dopa therapy induced a remarkable HVA increase and did not affect 5-HIAA levels in all areas of patients with hepatic coma.
AB - HVA and 5-HIAA levels have been assayed by fluorimetric method in medulla oblongata, griseum centralis pontis, substantia nigra, red nucleus, lamina quadrigemina, caudate nucleus, and lenticular nucleus of 21 patients deceased from non-neurological diseases. Levels of both acids were not affected by varying necropsy intervals, but HVA levels decreased with increasing age. Regardless of age, patients who deceased after prolonged coma showed increased 5-HIAA levels in all brain stem areas, especially in medulla oblongata. Such an increase was strikingly high in patients with hepatic coma but less pronounced in diabetic coma. HVA levels were increased in medulla oblongata of patients with hepatic coma, in all brain stem areas after diabetic coma, and were decreased in substantia nigra of comatose patients of various etiologies. L-dopa therapy induced a remarkable HVA increase and did not affect 5-HIAA levels in all areas of patients with hepatic coma.
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M3 - Article
VL - 33
SP - 487
EP - 500
JO - Acta Neurologica
JF - Acta Neurologica
SN - 0001-6276
IS - 6
ER -