Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation

Sebastian Giebel, Franco Locatelli, Jerzy Wojnar, Andrea Velardi, Tommaso Mina, Giovanna Giorgiani, Malgorzata Krawczyk-Kulis, Miroslaw Markiewicz, Iwona Wylezol, Jerzy Holowiecki

Research output: Contribution to journalArticlepeer-review

Abstract

Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0·01) and disease-free survival (P = 0·02), resulting from increased relapse rate (P = 0·02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalBritish Journal of Haematology
Volume131
Issue number4
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Human leucocyte antigen-C
  • Killer immunoglobulin-like receptor ligand
  • Relapse
  • Survival
  • Unrelated donor haematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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