Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections

Antonio Francavilla, Carmine Panella, Lorenzo Polimeno, Antonio Giangaspero, Vincenzo Mazzaferro, Chen En Pan, David H. Van Thiel, Thomas E. Starzl

Research output: Contribution to journalArticle

Abstract

Thirteen patients who underwent 40% to 80% removal of their livers had blood samples drawn initially and daily on postoperative days 1 to 7. The enzyme marker of heightened polyamine metabolism, ornithine decarboxylase, and the indicator of DNA synthesis, thymidine kinase, were measured. In addition, the hormones (insulin, glucagon, estradiol and androgen), which in animals are known to reflect and possibly modulate regeneration, were measured. Changes in all these indices followed the same pattern as in rats, dogs and swine but at a slower rate. Ornithine decarboxylase and estradiol increased within 24 hr, but thymidine kinase and insulin rises did not become statistically significant until 3 to 5 days. Using these plasma or serum indices as surrogate measures of biochemical events in the liver itself, regeneration reached a maximum after 4 or 5 days. By computed tomography scan analysis, restoration of hepatic cell mass was not complete until 3 wk.

Original languageEnglish
Pages (from-to)1134-1138
Number of pages5
JournalHepatology
Volume12
Issue number5
Publication statusPublished - Nov 1990

ASJC Scopus subject areas

  • Hepatology

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    Francavilla, A., Panella, C., Polimeno, L., Giangaspero, A., Mazzaferro, V., Pan, C. E., Van Thiel, D. H., & Starzl, T. E. (1990). Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. Hepatology, 12(5), 1134-1138.