Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections

Antonio Francavilla, Carmine Panella, Lorenzo Polimeno, Antonio Giangaspero, Vincenzo Mazzaferro, Chen En Pan, David H. Van Thiel, Thomas E. Starzl

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Thirteen patients who underwent 40% to 80% removal of their livers had blood samples drawn initially and daily on postoperative days 1 to 7. The enzyme marker of heightened polyamine metabolism, ornithine decarboxylase, and the indicator of DNA synthesis, thymidine kinase, were measured. In addition, the hormones (insulin, glucagon, estradiol and androgen), which in animals are known to reflect and possibly modulate regeneration, were measured. Changes in all these indices followed the same pattern as in rats, dogs and swine but at a slower rate. Ornithine decarboxylase and estradiol increased within 24 hr, but thymidine kinase and insulin rises did not become statistically significant until 3 to 5 days. Using these plasma or serum indices as surrogate measures of biochemical events in the liver itself, regeneration reached a maximum after 4 or 5 days. By computed tomography scan analysis, restoration of hepatic cell mass was not complete until 3 wk.

Original languageEnglish
Pages (from-to)1134-1138
Number of pages5
JournalHepatology
Volume12
Issue number5
Publication statusPublished - Nov 1990

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Ornithine Decarboxylase
Thymidine Kinase
Regeneration
Estradiol
Insulin
Liver Regeneration
Liver
Polyamines
Glucagon
Androgens
Hepatocytes
Swine
Tomography
Hormones
Dogs
DNA
Enzymes
Serum

ASJC Scopus subject areas

  • Hepatology

Cite this

Francavilla, A., Panella, C., Polimeno, L., Giangaspero, A., Mazzaferro, V., Pan, C. E., ... Starzl, T. E. (1990). Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. Hepatology, 12(5), 1134-1138.

Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. / Francavilla, Antonio; Panella, Carmine; Polimeno, Lorenzo; Giangaspero, Antonio; Mazzaferro, Vincenzo; Pan, Chen En; Van Thiel, David H.; Starzl, Thomas E.

In: Hepatology, Vol. 12, No. 5, 11.1990, p. 1134-1138.

Research output: Contribution to journalArticle

Francavilla, A, Panella, C, Polimeno, L, Giangaspero, A, Mazzaferro, V, Pan, CE, Van Thiel, DH & Starzl, TE 1990, 'Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections', Hepatology, vol. 12, no. 5, pp. 1134-1138.
Francavilla A, Panella C, Polimeno L, Giangaspero A, Mazzaferro V, Pan CE et al. Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. Hepatology. 1990 Nov;12(5):1134-1138.
Francavilla, Antonio ; Panella, Carmine ; Polimeno, Lorenzo ; Giangaspero, Antonio ; Mazzaferro, Vincenzo ; Pan, Chen En ; Van Thiel, David H. ; Starzl, Thomas E. / Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. In: Hepatology. 1990 ; Vol. 12, No. 5. pp. 1134-1138.
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