Hormonal and seminal evaluation of Leydig cell tumour patients before and after orchiectomy

S. Zarrilli, G. Lombardi, L. Pacsano, C. Di Somma, A. Colao, V. Mirone, M. De Rosa

Research output: Contribution to journalArticlepeer-review


Seven patients (aged 25 38 years) were admitted because of mono- or bilateral gynaecomastia. Plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testosterone, 17-β-estradiol, Δ4- androstenedione, dehydropiandrosterone sulphate (DHEA-S) and 17-OH- progesterone were determined and semen analysis was carried out. FSH and LH levels were also measured after acute LH-RH administration (100 μg intravenously), and testosterone and 17-β-estradiol were also evaluated after acute human chorionic gonadotrophin (hCG) administration (5000 IU intramuscularly). Testicular echography demonstrated the presence of a solid hypoechoic tumour. Therefore all patients were submitted to hemicastration by orchidofuniculotomy and a benign Leydig cell tumour was diagnosed in the removed testes. Hormonal and semen evaluations were repeated 3, 6, 9 and 12 months after surgery. The data before and after surgery were compared with a control group of 10 age-matched males. Before surgery, patients showed low FSH basal plasma levels; high levels of 17-β-estradiol and low testosterone levels similar to those after hCG administration. A dyspermia was observed. Unilateral orchidectomy eliminated the autonomous secretion of oestrogen(s) so an increase of LH, FSH and testosterone levels, together with an improvement of spermatogenesis, were obtained.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
Issue number3
Publication statusPublished - 2000


  • Gynaecomastia
  • Leydig cell tumour
  • Semen analysis
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Nephrology


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