Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia

Stefan D. Anker, Tuan Peng Chua, Piotr Ponikowski, Derek Harrington, Jon W. Swan, Wolfgang J. Kox, Philip A. Poole-Wilson, Andrew J S Coats

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The role of hormonal and cytokine abnormalities in the development of cardiac cachexia remains obscure. Methods and Results: Healthy control subjects (n=16) and patients with chronic heart failure (CHF), classified clinically as cachectic (8% to 35% weight loss over ≤6 months before study, n=16) or noncachectic (n=37), were assessed for markers of disease severity (maximal oxygen consumption, left ventricular ejection fraction, NYHA functional class). These markers were compared with plasma concentrations of potentially important anabolic and catabolic factors. The degree of neurohormonal activation and catabolic/anabolic imbalance was closely related to wasting but not to conventional measures of the severity of heart failure. Compared with control subjects and noncachectic patients, cachectic patients had reduced plasma sodium and increased norepinephrine, epinephrine (all P2=.50, P

Original languageEnglish
Pages (from-to)526-534
Number of pages9
JournalCirculation
Volume96
Issue number2
Publication statusPublished - Jul 15 1997

Keywords

  • Cachexia
  • Catecholamines
  • Heart failure
  • Hormones
  • Metabolism

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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