Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort - A factor analysis

Laure Dossus, Annekatrin Lukanova, Sabina Rinaldi, Naomi Allen, Anne E. Cust, Susen Becker, Anne Tjonneland, Louise Hansen, Kim Overvad, Nathalie Chabbert-Buffet, Sylvie Mesrine, Francoise Clavel-Chapelon, Birgit Teucher, Jenny Chang-Claude, Heiner Boeing, Dagmar Drogan, Antonia Trichopoulou, Vasiliki Benetou, Christina Bamia, Domenico PalliClaudia Agnoli, Rocco Galasso, Rosario Tumino, Carlotta Sacerdote, H. Bas Bueno-De-Mesquita, Fränzel J B Van Duijnhoven, Petra H M Peeters, N. Charlotte Onland-Moret, Maria Luisa Redondo, Noémie Travier, Maria Jose Sanchez, Jone M. Altzibar, Maria Dolores Chirlaque, Aurelio Barricarte, Eva Lundin, Kay Tee Khaw, Nicholas Wareham, Veronika Fedirko, Isabelle Romieu, Dora Romaguera, Teresa Norat, Elio Riboli, Rudolf Kaaks

Research output: Contribution to journalArticlepeer-review

Abstract

A "Western" lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992-2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled "insulin resistance/metabolic syndrome," "steroids," and "inflammation" factors. A fourth component, "lipids," was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis.

Original languageEnglish
Pages (from-to)787-799
Number of pages13
JournalAmerican Journal of Epidemiology
Volume177
Issue number8
DOIs
Publication statusPublished - Apr 15 2013

Keywords

  • endometrial neoplasms
  • factor analysis
  • hormones
  • inflammation
  • prospective studies

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort - A factor analysis'. Together they form a unique fingerprint.

Cite this