TY - JOUR
T1 - Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort - A factor analysis
AU - Dossus, Laure
AU - Lukanova, Annekatrin
AU - Rinaldi, Sabina
AU - Allen, Naomi
AU - Cust, Anne E.
AU - Becker, Susen
AU - Tjonneland, Anne
AU - Hansen, Louise
AU - Overvad, Kim
AU - Chabbert-Buffet, Nathalie
AU - Mesrine, Sylvie
AU - Clavel-Chapelon, Francoise
AU - Teucher, Birgit
AU - Chang-Claude, Jenny
AU - Boeing, Heiner
AU - Drogan, Dagmar
AU - Trichopoulou, Antonia
AU - Benetou, Vasiliki
AU - Bamia, Christina
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Galasso, Rocco
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Bueno-De-Mesquita, H. Bas
AU - Van Duijnhoven, Fränzel J B
AU - Peeters, Petra H M
AU - Onland-Moret, N. Charlotte
AU - Redondo, Maria Luisa
AU - Travier, Noémie
AU - Sanchez, Maria Jose
AU - Altzibar, Jone M.
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Lundin, Eva
AU - Khaw, Kay Tee
AU - Wareham, Nicholas
AU - Fedirko, Veronika
AU - Romieu, Isabelle
AU - Romaguera, Dora
AU - Norat, Teresa
AU - Riboli, Elio
AU - Kaaks, Rudolf
PY - 2013/4/15
Y1 - 2013/4/15
N2 - A "Western" lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992-2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled "insulin resistance/metabolic syndrome," "steroids," and "inflammation" factors. A fourth component, "lipids," was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis.
AB - A "Western" lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992-2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled "insulin resistance/metabolic syndrome," "steroids," and "inflammation" factors. A fourth component, "lipids," was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis.
KW - endometrial neoplasms
KW - factor analysis
KW - hormones
KW - inflammation
KW - prospective studies
UR - http://www.scopus.com/inward/record.url?scp=84876252959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876252959&partnerID=8YFLogxK
U2 - 10.1093/aje/kws309
DO - 10.1093/aje/kws309
M3 - Article
C2 - 23492765
AN - SCOPUS:84876252959
VL - 177
SP - 787
EP - 799
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 8
ER -