Hormonal regulation of postnatal growth in children born small for gestational age

S. Cianfarani, C. Ladaki, C. Geremia

Research output: Contribution to journalArticle

Abstract

Children born small for gestational age (SGA) are at high risk of permanent short stature, with approximately 10% continuing to have stature below the third centile throughout childhood and adolescence and into adulthood. The mechanisms involved in catch-up growth, and those that prevent catch-up growth, are still unknown. To date, no reliable anthropometric or endocrine parameter predictive of postnatal catch-up growth has been identified. However, subtle abnormalities in the growth hormone-insulin-like growth factor axis, the hypothalamic-pituitary-adrenal axis and thyroid function have been described, and a mechanism involving intrauterine programming of hypothalamic-pituitary function has been proposed.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalHormone Research
Volume65
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Apr 2006

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Keywords

  • Growth hormone
  • Hypothalamic-pituitary-adrenal axis
  • Insulin-like growth factor
  • Small for gestational age
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology

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