Hormonal replacement therapy after gynaecological cancer

Nicoletta Biglia, Luca Mariani, Davide Marenco, Claudio Robba, Elisa Peano, Franziska Kubatzki, Piero Sismondi

Research output: Contribution to journalArticlepeer-review


Thousands of women are treated each year for gynaecological cancers; many of these are already in menopause, while other younger patients will go into early menopause due to surgery, chemotherapy and/or radiotherapy to the pelvic region. The aim of this paper is to review the biological and clinical evidence in favour and against hormone replacement therapy (HRT) use after gynaecological cancers. With the exception of breast and endometrial cancer, there is no biological evidence that HRT may increase the recurrence risk. In women with previous endometrial cancer, HRT use is not supported by univocal and conclusive data to formulate specific recommendations, whereas most authors suggest that oestrogens may be used after adequate information about risks and benefits. The use of HRT in breast cancer patients is, at present, considered contra-indicated, even if results of clinical trials are not concordant. Therapeutic nonhormonal alternatives may be proposed to these patients.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalGynakologisch-geburtshilfliche Rundschau
Issue number4
Publication statusPublished - Oct 2006


  • Gynaecological and breast cancer survivors
  • Hormone replacement therapy
  • Menopause

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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