Hormonal replacement therapy is prescribed both to relieve menopausal symptoms and for preventive purposes. The preventive benefit, however, is dubious because the increased risk of breast cancer may be more important than the decreased risk of myocardial infarction and osteoporotic fractures. The transdermal administration may be associated with higher breast cancer risk and lower cardiovascular benefit than the oral administration; only the latter, in fact, is able to stimulate the liver synthesis of sex hormone binding globulin (SHBG, which reduces the availability of testosterone and estradiol to target organs) and of HDL cholesterol, and to inhibit the liver synthesis of IGF-I (which cooperates with sex steroids to enhance the breast cancer cell proliferation).
|Translated title of the contribution||Hormonal replacement therapy: Therapeutical benefits and preventive risks|
|Number of pages||3|
|Journal||Annali dell'Istituto Superiore di Sanita|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health