Hormonal therapy for fertility and huge meningioma: A purely random association?

Paolo Frassanito, Pasquale de Bonis, Pier Paolo Mattogno, Mariangela Novello, Carmelo Anile

Research output: Contribution to journalArticlepeer-review


Sexual hormones have been related to the growth of meningiomas, also due to the almost constant expression of hormonal receptors by tumoral cells. A case of a woman with previous history of multiple treatment for infertility, harboring a huge meningioma is here described. The tumor was surgically resected and the immunohistochemical examination revealed a high expression of progesterone receptors on tumoral cells surface. A putative role of past progesterone administration in the growth of meningioma has been hypothesized. Particular caution should be paid whenever adopting sexual hormonal therapy, especially for fertility. A radiological examination (ideally MRI) could be advised before starting therapy, in order to rule out any intracranial meningioma.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalActa Neurologica Belgica
Issue number3
Publication statusPublished - 2012


  • Fertility therapy
  • Meningioma
  • Progesterone
  • Sex hormonal receptors

ASJC Scopus subject areas

  • Clinical Neurology


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