TY - JOUR
T1 - Hormonal therapy for fertility and huge meningioma
T2 - A purely random association?
AU - Frassanito, Paolo
AU - de Bonis, Pasquale
AU - Mattogno, Pier Paolo
AU - Novello, Mariangela
AU - Anile, Carmelo
PY - 2012
Y1 - 2012
N2 - Sexual hormones have been related to the growth of meningiomas, also due to the almost constant expression of hormonal receptors by tumoral cells. A case of a woman with previous history of multiple treatment for infertility, harboring a huge meningioma is here described. The tumor was surgically resected and the immunohistochemical examination revealed a high expression of progesterone receptors on tumoral cells surface. A putative role of past progesterone administration in the growth of meningioma has been hypothesized. Particular caution should be paid whenever adopting sexual hormonal therapy, especially for fertility. A radiological examination (ideally MRI) could be advised before starting therapy, in order to rule out any intracranial meningioma.
AB - Sexual hormones have been related to the growth of meningiomas, also due to the almost constant expression of hormonal receptors by tumoral cells. A case of a woman with previous history of multiple treatment for infertility, harboring a huge meningioma is here described. The tumor was surgically resected and the immunohistochemical examination revealed a high expression of progesterone receptors on tumoral cells surface. A putative role of past progesterone administration in the growth of meningioma has been hypothesized. Particular caution should be paid whenever adopting sexual hormonal therapy, especially for fertility. A radiological examination (ideally MRI) could be advised before starting therapy, in order to rule out any intracranial meningioma.
KW - Fertility therapy
KW - Meningioma
KW - Progesterone
KW - Sex hormonal receptors
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U2 - 10.1007/s13760-012-0046-9
DO - 10.1007/s13760-012-0046-9
M3 - Article
C2 - 22426675
AN - SCOPUS:84866120109
VL - 112
SP - 299
EP - 301
JO - Acta Neurologica Belgica
JF - Acta Neurologica Belgica
SN - 0300-9108
IS - 3
ER -