Abstract
Exocrine pancreas carcinoma is still diagnosed at a relatively late stage, so that only a few cases can be cured by surgery. Therefore, it is desirable that an effective medical therapy be found first to stall the development of the disease and second to improve the life conditions of patients. On the basis of recent discoveries, a new therapeutic approach seems to derive from hormone manipulation. The growth of pancreatic carcinoma appears to be stimulated by various factors, such as Epidermal Growth Factor (EGF) and Insulin-like Growth Factor I (IGF-I), and by various hormones, such as androgens and cholecystokinin. Several studies performed on cell lines and on animal models of pancreatic carcinoma demonstrated an antitumoral effect of certain antihormones and of somatostatin. Taking such studies as a premise, the first clinical studies were finally started in patients suffering from nonoperable pancreatic cancer. Results are still partial and contradictory, but such research is certainly worthy of further study along the lines already taken.
| Original language | English |
|---|---|
| Pages (from-to) | 159-168 |
| Number of pages | 10 |
| Journal | International Journal of Pancreatology |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1993 |
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Keywords
- Gastrointestinal hormones
- growth factors
- sex hormones
- somatostatin
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Endocrinology
Cite this
Hormonal therapy of pancreatic carcinoma - Rationale and perspectives. / Perilli, Daniele; Mansi, Carlo; Savarino, Vincenzo; Celle, Guido.
In: International Journal of Pancreatology, Vol. 13, No. 3, 06.1993, p. 159-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal therapy of pancreatic carcinoma - Rationale and perspectives
AU - Perilli, Daniele
AU - Mansi, Carlo
AU - Savarino, Vincenzo
AU - Celle, Guido
PY - 1993/6
Y1 - 1993/6
N2 - Exocrine pancreas carcinoma is still diagnosed at a relatively late stage, so that only a few cases can be cured by surgery. Therefore, it is desirable that an effective medical therapy be found first to stall the development of the disease and second to improve the life conditions of patients. On the basis of recent discoveries, a new therapeutic approach seems to derive from hormone manipulation. The growth of pancreatic carcinoma appears to be stimulated by various factors, such as Epidermal Growth Factor (EGF) and Insulin-like Growth Factor I (IGF-I), and by various hormones, such as androgens and cholecystokinin. Several studies performed on cell lines and on animal models of pancreatic carcinoma demonstrated an antitumoral effect of certain antihormones and of somatostatin. Taking such studies as a premise, the first clinical studies were finally started in patients suffering from nonoperable pancreatic cancer. Results are still partial and contradictory, but such research is certainly worthy of further study along the lines already taken.
AB - Exocrine pancreas carcinoma is still diagnosed at a relatively late stage, so that only a few cases can be cured by surgery. Therefore, it is desirable that an effective medical therapy be found first to stall the development of the disease and second to improve the life conditions of patients. On the basis of recent discoveries, a new therapeutic approach seems to derive from hormone manipulation. The growth of pancreatic carcinoma appears to be stimulated by various factors, such as Epidermal Growth Factor (EGF) and Insulin-like Growth Factor I (IGF-I), and by various hormones, such as androgens and cholecystokinin. Several studies performed on cell lines and on animal models of pancreatic carcinoma demonstrated an antitumoral effect of certain antihormones and of somatostatin. Taking such studies as a premise, the first clinical studies were finally started in patients suffering from nonoperable pancreatic cancer. Results are still partial and contradictory, but such research is certainly worthy of further study along the lines already taken.
KW - Gastrointestinal hormones
KW - growth factors
KW - sex hormones
KW - somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0027175509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027175509&partnerID=8YFLogxK
U2 - 10.1007/BF02924436
DO - 10.1007/BF02924436
M3 - Article
C2 - 8103783
AN - SCOPUS:0027175509
VL - 13
SP - 159
EP - 168
JO - International Journal of Gastrointestinal Cancer
JF - International Journal of Gastrointestinal Cancer
SN - 1537-3649
IS - 3
ER -