Hormone replacement therapy and chronic graft-versus-host disease activity in women treated with bone marrow transplantation for hematologic malignancies

Enrico Balleari, Simona Garrè, Maria Teresa Van Lint, Simonetta Spinelli, Sandra Chiodi, Enrico Repetto, Giulio Massa, Andrea Bacigalupo, Riccardo Ghio

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of experimental evidence suggest that sex hormones may influence the development and activity of chronic graft-versus-host disease (cGVHD), which frequently occurs in patients undergoing allogeneic bone marrow transplantation (ABMT). Following ABMT, young women are commonly treated with hormone replacement therapy (HRT) because of irreversible gonadal failure. It seemed therefore worthwhile to investigate the effects of this therapy on the activity of cGVHD. Premenopausal women treated with ABMT for hematological malignancies between January 1997 and December 2000 were evaluated for cGVHD activity. They were divided into two groups, depending on whether or not they were treated with HRT. Seventy-one women qualified for the present study: 39 received HRT (treated group), while 32 did not (controls). In both groups of patients, cGVHD activity score was comparable before the start of HRT. No differences were observed in cGVHD activity score between the HRT group and controls after 3, 6, 12, and 24 months from the start of HRT. Furthermore, HRT did not induce any increase in the cGVHD activity score in the treated group of patients at any time from the start of HRT. According to present data, HRT did not appear to influence the activity of cGVHD in young women who underwent ABMT for hematological malignancies. Therefore, we can safely propose this therapy for women with gonadal failure after ABMT.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume966
Publication statusPublished - 2002

Keywords

  • Bone marrow transplantation
  • Estrogens
  • Graft-versus-host disease
  • Hormone replacement therapy
  • Leukemia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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