TY - JOUR
T1 - Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy
AU - Tavani, Alessandra
AU - Bertuzzi, Michaela
AU - Gallus, Silvano
AU - Negri, Eva
AU - La Vecchia, Carlo
PY - 2005/7
Y1 - 2005/7
N2 - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
AB - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
KW - Acute myocardial infarction
KW - Case-control studies
KW - Epidemiology
KW - Hormone replacement therapy
KW - Risk factors
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U2 - 10.1016/j.jclinepi.2004.01.023
DO - 10.1016/j.jclinepi.2004.01.023
M3 - Article
C2 - 15939229
AN - SCOPUS:20444412719
VL - 58
SP - 747
EP - 750
JO - American journal of syphilis, gonorrhea, and venereal diseases
JF - American journal of syphilis, gonorrhea, and venereal diseases
SN - 0895-4356
IS - 7
ER -