Abstract
Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
| Original language | English |
|---|---|
| Pages (from-to) | 747-750 |
| Number of pages | 4 |
| Journal | Journal of Clinical Epidemiology |
| Volume | 58 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2005 |
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Keywords
- Acute myocardial infarction
- Case-control studies
- Epidemiology
- Hormone replacement therapy
- Risk factors
ASJC Scopus subject areas
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Epidemiology
Cite this
Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy. / Tavani, Alessandra; Bertuzzi, Michaela; Gallus, Silvano; Negri, Eva; La Vecchia, Carlo.
In: Journal of Clinical Epidemiology, Vol. 58, No. 7, 07.2005, p. 747-750.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy
AU - Tavani, Alessandra
AU - Bertuzzi, Michaela
AU - Gallus, Silvano
AU - Negri, Eva
AU - La Vecchia, Carlo
PY - 2005/7
Y1 - 2005/7
N2 - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
AB - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.
KW - Acute myocardial infarction
KW - Case-control studies
KW - Epidemiology
KW - Hormone replacement therapy
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=20444412719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444412719&partnerID=8YFLogxK
U2 - 10.1016/j.jclinepi.2004.01.023
DO - 10.1016/j.jclinepi.2004.01.023
M3 - Article
VL - 58
SP - 747
EP - 750
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
IS - 7
ER -