Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy

Alessandra Tavani; Michaela Bertuzzi; Silvano Gallus; Eva Negri; Carlo La Vecchia

doi:10.1016/j.jclinepi.2004.01.023

Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy

Alessandra Tavani, Michaela Bertuzzi, Silvano Gallus, Eva Negri, Carlo La Vecchia

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.

Original language	English
Pages (from-to)	747-750
Number of pages	4
Journal	Journal of Clinical Epidemiology
Volume	58
Issue number	7
DOIs	https://doi.org/10.1016/j.jclinepi.2004.01.023
Publication status	Published - Jul 2005

Keywords

Acute myocardial infarction
Case-control studies
Epidemiology
Hormone replacement therapy
Risk factors

ASJC Scopus subject areas

Medicine(all)
Public Health, Environmental and Occupational Health
Epidemiology

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Tavani, A., Bertuzzi, M., Gallus, S., Negri, E., & La Vecchia, C. (2005). Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy. Journal of Clinical Epidemiology, 58(7), 747-750. https://doi.org/10.1016/j.jclinepi.2004.01.023

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abstract = "Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.",

keywords = "Acute myocardial infarction, Case-control studies, Epidemiology, Hormone replacement therapy, Risk factors",

author = "Alessandra Tavani and Michaela Bertuzzi and Silvano Gallus and Eva Negri and {La Vecchia}, Carlo",

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AU - Tavani, Alessandra

AU - Bertuzzi, Michaela

AU - Gallus, Silvano

AU - Negri, Eva

AU - La Vecchia, Carlo

PY - 2005/7

Y1 - 2005/7

N2 - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.

AB - Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.

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KW - Epidemiology

KW - Hormone replacement therapy

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