Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy

Alessandra Tavani, Michaela Bertuzzi, Silvano Gallus, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Background: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. Methods: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls. Results: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. Conclusions: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.

Original languageEnglish
Pages (from-to)747-750
Number of pages4
JournalJournal of Clinical Epidemiology
Issue number7
Publication statusPublished - Jul 2005


  • Acute myocardial infarction
  • Case-control studies
  • Epidemiology
  • Hormone replacement therapy
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology


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