Hormone supplementation differently affects migraine in postmenopausal women

F. Facchinetti, R. E. Nappi, A. Tirelli, F. Polatti, G. Nappi

Research output: Contribution to journalArticlepeer-review


Objective. To evaluate the effects of three schemes of oral hormone replacement therapy (HRT) on migraine course in postmenopausal women. Methods. Thirty-eight patients presenting for clinical evaluation of menopausal status and suffering from migraine were enrolled. The observational period lasted 7 months, during which women filled in a daily diary with the clinical features of headache attacks and analgesic use. We evaluated climacteric symptoms, anxiety and depression. After a 1-month run-in period, women were assigned to one of three regimens of HRT: estradiol hemihydrate 1 mg/day plus norethisterone 0.5 mg/day for 28 days, in a continuous combined scheme; oral conjugated estrogens 0.625 mg/day for 28 days plus medroxyprogesterone acetate 10 mg/day in the last 14 days, in a sequential continuous scheme; and estradiol valerate 2 mg/day for 21 days plus cyproterone acetate 1 mg/day from day 12 to 21 in a sequential cyclical scheme. Follow-up evaluations were performed at 3 and 6 months. Results. During the run-in period, the three subgroups of patients were similar as far as the features of migraine are concerned. Overall, a progressive increase in attack frequency (from 2.2 ± 1.0 to 3.8 ± 1.3, P

Original languageEnglish
Pages (from-to)924-929
Number of pages6
Issue number9
Publication statusPublished - Oct 2002


  • Hormones
  • Migraine
  • Postmenopause

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Hormone supplementation differently affects migraine in postmenopausal women'. Together they form a unique fingerprint.

Cite this