Hospitalizations in pediatric and adult patients for all cancer type in Italy: The EPIKIT study under the E.U. COHEIRS project on environment and health

Prisco Piscitelli, Immacolata Marino, Andrea Falco, Matteo Rivezzi, Roberto Romano, Restituta Mazzella, Cosimo Neglia, Giulia Della Rosa, Giuseppe Pellerano, Giuseppe Militerno, Adriana Bonifacino, Gaetano Rivezzi, Roberto Romizi, Giuseppe Miserotti, Maurizio Montella, Fabrizio Bianchi, Alessandra Marinelli, Antonella De Donno, Giovanni De Filippis, Giuseppe SerravezzaGianluca Di Tanna, Dennis Black, Valerio Gennaro, Mario Ascolese, Alessandro Distante, Ernesto Burgio, Massimo Crespi, Annamaria Colao

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Cancer Registries (CRs) remain the gold standard for providing official epidemiological estimations. However, due to CRs’ partial population coverage, hospitalization records might represent a valuable tool to provide additional information on cancer occurrence and expenditures at national/regional level for research purposes. The Epidemiology of Cancer in Italy (EPIKIT) study group has been built up, within the framework of the Civic Observers for Health and Environment: Initiative of Responsibility and Sustainability (COHEIRS) project under the auspices of the Europe for Citizens Program, to assess population health indicators. Objective: To assess the burden of all cancers in Italian children and adults. Methods: We analyzed National Hospitalization Records from 2001 to 2011. Based on social security numbers (anonymously treated), we have excluded from our analyses all re-hospitalizations of the same patients (n = 1,878,109) over the entire 11-year period in order to minimize the overlap between prevalent and incident cancer cases. To be more conservative, only data concerning the last five years (2007–2011) have been taken into account for final analyses. The absolute number of hospitalizations and standardized hospitalization rates (SHR) were computed for each Italian province by sex and age-groups (0–19 and 20–49). Results: The EPIKIT database included a total of 4,113,169 first hospital admissions due to main diagnoses of all tumors. The annual average number of hospital admissions due to cancer in Italy has been computed in 2362 and 43,141 hospitalizations in pediatric patients (0–19 years old) and adults (20–49 years old), respectively. Women accounted for the majority of cancer cases in adults aged 20–49. As expected, the big city of Rome presented the highest average annual number of pediatric cancers (n = 392, SHR = 9.9), followed by Naples (n = 378; SHR = 9.9) and Milan (n = 212; SHR = 7.3). However, when we look at SHR, minor cities (i.e., Imperia, Isernia and others) presented values >10 per 100,000, with only 10 or 20 cases per year. Similar figures are shown also for young adults aged 20–49. Conclusions: In addition to SHR, the absolute number of incident cancer cases represents a crucial piece of information for planning adequate healthcare services and assessing social alarm phenomena. Our findings call for specific risk assessment programs at local level (involving CRs) to search for causal relations with environmental exposures.

Original languageEnglish
Article number495
JournalInternational Journal of Environmental Research and Public Health
Volume14
Issue number5
DOIs
Publication statusPublished - May 9 2017

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Italy
Hospitalization
Pediatrics
Health
Neoplasms
Registries
Social Security
Environmental Exposure
Health Expenditures
Social Work
Population
Young Adult
Epidemiology
Age Groups
Databases
Delivery of Health Care

Keywords

  • Adult cancer
  • Cancer incidence
  • Children
  • Environment and health
  • Hospitalizations
  • Pediatric cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Hospitalizations in pediatric and adult patients for all cancer type in Italy : The EPIKIT study under the E.U. COHEIRS project on environment and health. / Piscitelli, Prisco; Marino, Immacolata; Falco, Andrea; Rivezzi, Matteo; Romano, Roberto; Mazzella, Restituta; Neglia, Cosimo; Rosa, Giulia Della; Pellerano, Giuseppe; Militerno, Giuseppe; Bonifacino, Adriana; Rivezzi, Gaetano; Romizi, Roberto; Miserotti, Giuseppe; Montella, Maurizio; Bianchi, Fabrizio; Marinelli, Alessandra; De Donno, Antonella; De Filippis, Giovanni; Serravezza, Giuseppe; Di Tanna, Gianluca; Black, Dennis; Gennaro, Valerio; Ascolese, Mario; Distante, Alessandro; Burgio, Ernesto; Crespi, Massimo; Colao, Annamaria.

In: International Journal of Environmental Research and Public Health, Vol. 14, No. 5, 495, 09.05.2017.

Research output: Contribution to journalArticle

Piscitelli, P, Marino, I, Falco, A, Rivezzi, M, Romano, R, Mazzella, R, Neglia, C, Rosa, GD, Pellerano, G, Militerno, G, Bonifacino, A, Rivezzi, G, Romizi, R, Miserotti, G, Montella, M, Bianchi, F, Marinelli, A, De Donno, A, De Filippis, G, Serravezza, G, Di Tanna, G, Black, D, Gennaro, V, Ascolese, M, Distante, A, Burgio, E, Crespi, M & Colao, A 2017, 'Hospitalizations in pediatric and adult patients for all cancer type in Italy: The EPIKIT study under the E.U. COHEIRS project on environment and health', International Journal of Environmental Research and Public Health, vol. 14, no. 5, 495. https://doi.org/10.3390/ijerph14050495
Piscitelli, Prisco ; Marino, Immacolata ; Falco, Andrea ; Rivezzi, Matteo ; Romano, Roberto ; Mazzella, Restituta ; Neglia, Cosimo ; Rosa, Giulia Della ; Pellerano, Giuseppe ; Militerno, Giuseppe ; Bonifacino, Adriana ; Rivezzi, Gaetano ; Romizi, Roberto ; Miserotti, Giuseppe ; Montella, Maurizio ; Bianchi, Fabrizio ; Marinelli, Alessandra ; De Donno, Antonella ; De Filippis, Giovanni ; Serravezza, Giuseppe ; Di Tanna, Gianluca ; Black, Dennis ; Gennaro, Valerio ; Ascolese, Mario ; Distante, Alessandro ; Burgio, Ernesto ; Crespi, Massimo ; Colao, Annamaria. / Hospitalizations in pediatric and adult patients for all cancer type in Italy : The EPIKIT study under the E.U. COHEIRS project on environment and health. In: International Journal of Environmental Research and Public Health. 2017 ; Vol. 14, No. 5.
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abstract = "Background: Cancer Registries (CRs) remain the gold standard for providing official epidemiological estimations. However, due to CRs’ partial population coverage, hospitalization records might represent a valuable tool to provide additional information on cancer occurrence and expenditures at national/regional level for research purposes. The Epidemiology of Cancer in Italy (EPIKIT) study group has been built up, within the framework of the Civic Observers for Health and Environment: Initiative of Responsibility and Sustainability (COHEIRS) project under the auspices of the Europe for Citizens Program, to assess population health indicators. Objective: To assess the burden of all cancers in Italian children and adults. Methods: We analyzed National Hospitalization Records from 2001 to 2011. Based on social security numbers (anonymously treated), we have excluded from our analyses all re-hospitalizations of the same patients (n = 1,878,109) over the entire 11-year period in order to minimize the overlap between prevalent and incident cancer cases. To be more conservative, only data concerning the last five years (2007–2011) have been taken into account for final analyses. The absolute number of hospitalizations and standardized hospitalization rates (SHR) were computed for each Italian province by sex and age-groups (0–19 and 20–49). Results: The EPIKIT database included a total of 4,113,169 first hospital admissions due to main diagnoses of all tumors. The annual average number of hospital admissions due to cancer in Italy has been computed in 2362 and 43,141 hospitalizations in pediatric patients (0–19 years old) and adults (20–49 years old), respectively. Women accounted for the majority of cancer cases in adults aged 20–49. As expected, the big city of Rome presented the highest average annual number of pediatric cancers (n = 392, SHR = 9.9), followed by Naples (n = 378; SHR = 9.9) and Milan (n = 212; SHR = 7.3). However, when we look at SHR, minor cities (i.e., Imperia, Isernia and others) presented values >10 per 100,000, with only 10 or 20 cases per year. Similar figures are shown also for young adults aged 20–49. Conclusions: In addition to SHR, the absolute number of incident cancer cases represents a crucial piece of information for planning adequate healthcare services and assessing social alarm phenomena. Our findings call for specific risk assessment programs at local level (involving CRs) to search for causal relations with environmental exposures.",
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author = "Prisco Piscitelli and Immacolata Marino and Andrea Falco and Matteo Rivezzi and Roberto Romano and Restituta Mazzella and Cosimo Neglia and Rosa, {Giulia Della} and Giuseppe Pellerano and Giuseppe Militerno and Adriana Bonifacino and Gaetano Rivezzi and Roberto Romizi and Giuseppe Miserotti and Maurizio Montella and Fabrizio Bianchi and Alessandra Marinelli and {De Donno}, Antonella and {De Filippis}, Giovanni and Giuseppe Serravezza and {Di Tanna}, Gianluca and Dennis Black and Valerio Gennaro and Mario Ascolese and Alessandro Distante and Ernesto Burgio and Massimo Crespi and Annamaria Colao",
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TY - JOUR

T1 - Hospitalizations in pediatric and adult patients for all cancer type in Italy

T2 - The EPIKIT study under the E.U. COHEIRS project on environment and health

AU - Piscitelli, Prisco

AU - Marino, Immacolata

AU - Falco, Andrea

AU - Rivezzi, Matteo

AU - Romano, Roberto

AU - Mazzella, Restituta

AU - Neglia, Cosimo

AU - Rosa, Giulia Della

AU - Pellerano, Giuseppe

AU - Militerno, Giuseppe

AU - Bonifacino, Adriana

AU - Rivezzi, Gaetano

AU - Romizi, Roberto

AU - Miserotti, Giuseppe

AU - Montella, Maurizio

AU - Bianchi, Fabrizio

AU - Marinelli, Alessandra

AU - De Donno, Antonella

AU - De Filippis, Giovanni

AU - Serravezza, Giuseppe

AU - Di Tanna, Gianluca

AU - Black, Dennis

AU - Gennaro, Valerio

AU - Ascolese, Mario

AU - Distante, Alessandro

AU - Burgio, Ernesto

AU - Crespi, Massimo

AU - Colao, Annamaria

PY - 2017/5/9

Y1 - 2017/5/9

N2 - Background: Cancer Registries (CRs) remain the gold standard for providing official epidemiological estimations. However, due to CRs’ partial population coverage, hospitalization records might represent a valuable tool to provide additional information on cancer occurrence and expenditures at national/regional level for research purposes. The Epidemiology of Cancer in Italy (EPIKIT) study group has been built up, within the framework of the Civic Observers for Health and Environment: Initiative of Responsibility and Sustainability (COHEIRS) project under the auspices of the Europe for Citizens Program, to assess population health indicators. Objective: To assess the burden of all cancers in Italian children and adults. Methods: We analyzed National Hospitalization Records from 2001 to 2011. Based on social security numbers (anonymously treated), we have excluded from our analyses all re-hospitalizations of the same patients (n = 1,878,109) over the entire 11-year period in order to minimize the overlap between prevalent and incident cancer cases. To be more conservative, only data concerning the last five years (2007–2011) have been taken into account for final analyses. The absolute number of hospitalizations and standardized hospitalization rates (SHR) were computed for each Italian province by sex and age-groups (0–19 and 20–49). Results: The EPIKIT database included a total of 4,113,169 first hospital admissions due to main diagnoses of all tumors. The annual average number of hospital admissions due to cancer in Italy has been computed in 2362 and 43,141 hospitalizations in pediatric patients (0–19 years old) and adults (20–49 years old), respectively. Women accounted for the majority of cancer cases in adults aged 20–49. As expected, the big city of Rome presented the highest average annual number of pediatric cancers (n = 392, SHR = 9.9), followed by Naples (n = 378; SHR = 9.9) and Milan (n = 212; SHR = 7.3). However, when we look at SHR, minor cities (i.e., Imperia, Isernia and others) presented values >10 per 100,000, with only 10 or 20 cases per year. Similar figures are shown also for young adults aged 20–49. Conclusions: In addition to SHR, the absolute number of incident cancer cases represents a crucial piece of information for planning adequate healthcare services and assessing social alarm phenomena. Our findings call for specific risk assessment programs at local level (involving CRs) to search for causal relations with environmental exposures.

AB - Background: Cancer Registries (CRs) remain the gold standard for providing official epidemiological estimations. However, due to CRs’ partial population coverage, hospitalization records might represent a valuable tool to provide additional information on cancer occurrence and expenditures at national/regional level for research purposes. The Epidemiology of Cancer in Italy (EPIKIT) study group has been built up, within the framework of the Civic Observers for Health and Environment: Initiative of Responsibility and Sustainability (COHEIRS) project under the auspices of the Europe for Citizens Program, to assess population health indicators. Objective: To assess the burden of all cancers in Italian children and adults. Methods: We analyzed National Hospitalization Records from 2001 to 2011. Based on social security numbers (anonymously treated), we have excluded from our analyses all re-hospitalizations of the same patients (n = 1,878,109) over the entire 11-year period in order to minimize the overlap between prevalent and incident cancer cases. To be more conservative, only data concerning the last five years (2007–2011) have been taken into account for final analyses. The absolute number of hospitalizations and standardized hospitalization rates (SHR) were computed for each Italian province by sex and age-groups (0–19 and 20–49). Results: The EPIKIT database included a total of 4,113,169 first hospital admissions due to main diagnoses of all tumors. The annual average number of hospital admissions due to cancer in Italy has been computed in 2362 and 43,141 hospitalizations in pediatric patients (0–19 years old) and adults (20–49 years old), respectively. Women accounted for the majority of cancer cases in adults aged 20–49. As expected, the big city of Rome presented the highest average annual number of pediatric cancers (n = 392, SHR = 9.9), followed by Naples (n = 378; SHR = 9.9) and Milan (n = 212; SHR = 7.3). However, when we look at SHR, minor cities (i.e., Imperia, Isernia and others) presented values >10 per 100,000, with only 10 or 20 cases per year. Similar figures are shown also for young adults aged 20–49. Conclusions: In addition to SHR, the absolute number of incident cancer cases represents a crucial piece of information for planning adequate healthcare services and assessing social alarm phenomena. Our findings call for specific risk assessment programs at local level (involving CRs) to search for causal relations with environmental exposures.

KW - Adult cancer

KW - Cancer incidence

KW - Children

KW - Environment and health

KW - Hospitalizations

KW - Pediatric cancer

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