Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

Alan Winston, Wolfgang Stöhr, Andrea Antinori, A. Arenas-Pinto, Josep Maria Llibre, H. Amieva, A. Cabié, Ian Williams, Giovanni Di Perri, M. J. Tellez, J. Rockstroh, Abdel Babiker, A. Pozniak, F. Raffi, L. Richert, N. Dedes, Genevieve Chene, Clotilde Allavena, Brigitte Autran, R. BucciardiniS. Vella, A. Horban, J. Arribas, Marta Boffito, Deenan Pillay, X. Franquet, Siegfried Schwarze, Jesper Grarup, Aurelie Fischer, Cédrick Wallet, Alpha Diallo, Jean Michel Molina, Juliette Saillard, Christiane Moecklinghoff, H. J. Stellbrink, Remko Leeuwen, Jose Gatell, E. Sandström, Markus Flepp, Fiona Ewings, Elizabeth C. George, F. Hudson, Gillian Pearce, Romina Quercia, Felipe Rogatto, Randi Leavitt, Bach Yen Nguyen, Frank Detlev Goebel, Simone Marcotullio, Navrup Kaur, Peter Sasieni, Christina Spencer-Drake, T. E A Peto, V. Miller, Geneviève Chêne, Fabien Arnault, Céline Boucherie, Aurélie Fischer, Delphine Jean, Virginie Paniego, Elodie Rouch, Christine Schwimmer, Malika Soussi, Audrey Taieb, Monique Termote, Guillaume Touzeau, Cédrick Wallet, Adam Cursley, W. Dodds, Anne Hoppe, Ischa Kummeling, Filippo Pacciarini, Nick Paton, Charlotte Russell, Kay Taylor, Denise Ward, Bitten Aagaard, Marius Eid, Daniela Gey, B. G. Jensen, Marie Louise Jakobsen, Per Olof Jansson, Karoline Jensen, Zillah Maria Joensen, Ellen Moseholm Larsen, Christiane Pahl, M. Pearson, Birgit Riis Nielsen, Søren Reilev, Ilse Christ, Desiree Lathouwers, Corry Manting, Bienvenu Yves Mendy, Annie Metro, Sandrine Couffin-Cadiergues, Anne Laure Knellwolf, Lucia Palmisiano, Esther Aznar, Cristina Barea, Manuel Cotarelo, Herminia Esteban, Iciar Girbau, Beatriz Moyano, Miriam Ramirez, Carmen Saiz, Isabel Sanchez, Maria Yllescas, Andrea Binelli, Valentina Colasanti, Valentina Colasanti, Olga Anagnostou, Vicky Gioukari, Giota Touloumi, Brigitte Schmied, Armin Rieger, N. Vetter, Stephane D. Wit, E. Florence, L. Vandekerckhove, J. Gerstoft, L. Mathiesen, Christine Katlama, A. Cabié, Antoine Cheret, M. Dupon, Jade Ghosn, Pierre Marie Girard, C. Goujard, Y. Levy, P. Morlat, D. Neau, Martine Obadia, Philippe Perre, Lionel Piroth, Jacques Reynes, Pierre Tattevin, J. M. Ragnaud, L. Weiss, Yazdanpanah Yazdan, P. Yeni, David Zucman, Georg Behrens, S. Esser, Gerd Fätkenheuer, Christian Hoffmann, H. Jessen, Reinhold E. Schmidt, Christoph Stephan, Stefan Unger, A. Hatzakis, G. L. Daikos, A. Papadopoulos, Athamasios Skoutelis, Denes Banhegyi, Paddy Mallon, F. Mulcahy, M. Andreoni, S. Bonora, Francesco Castelli, Antonella D. Monforte, Massimo Galli, A. Lazzarin, Adriano Lazzarin, Torti Carlo, Vincenzo Vullo, J. M. Prins, C. Richter, D. W M Verhagen, Arne Eeden, M. Doroana, Francisco Antunes, F. Maltez, Rui Sarmento-Castro, Juan Gonzalez Garcia, José López Aldeguer, B. Clotet, P. Domingo, J. M. Gatell, H. Knobel, Manuel Marquez, Martin Pilar Miralles, Joaquín Portilla, V. Soriano, A. Thalme, A. Blaxhult, Magnus Gisslén, J. Fox, M. M. Gompels, Elbushra Herieka, Margaret Johnson, C. Leen, Alastair Teague, Mark Alastair Boyd, Nina Friis Moller, Ellen Frøsig, Vincent Moing, Ferdinand Wit, J. Kowalska, Juan Berenguer, Santiago Moreno, Nicolas J. MuHller, Estée Török, Frank A. Post, B. J. Angus, V. Calvez, C. A B Boucher, Simon Collins, D. Dunn, Sidonie Lambert, Anne Geneviève Marcelin, Carlo Perno, Carlo Federico Perno, Adriana Ammassari, Adriana Ammassari, Reinhold Schmidt, Michal Odermarsky, Colette Smith, Rodolphe Thiebaut, Bernardino LaSerna, A. Castagna, Antonella Castagna, Amanda Mocroft, Peter Reiss, V. Fragola, Marco Lauriola, R. Murri, Pythia Nieuwkerk, B. Spire, Alain Volny-Anne, Brian West, Josep Maria, Marco Braggion, Emanuele Focà

Research output: Contribution to journalArticle

Abstract

Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalHIV Medicine
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • antiretroviral naïve
  • cognitive
  • HIV
  • neuropsychological tests

ASJC Scopus subject areas

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)

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    Winston, A., Stöhr, W., Antinori, A., Arenas-Pinto, A., Llibre, J. M., Amieva, H., Cabié, A., Williams, I., Di Perri, G., Tellez, M. J., Rockstroh, J., Babiker, A., Pozniak, A., Raffi, F., Richert, L., Dedes, N., Chene, G., Allavena, C., Autran, B., ... Focà, E. (2016). Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy. HIV Medicine, 17(6), 471-478. https://doi.org/10.1111/hiv.12344