Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin

I. Abbate, M. R. Capobianchi, S. Fais, C. Castilletti, F. Mercuri, P. Cordiali Fei, F. Ameglio, F. Dianzani

Research output: Contribution to journalArticle

Abstract

HIV-1 acquires cell membrane proteins during budding. The cell membrane proteins (CMP) profile of laboratory HIV-1 strains grown in different host cells was established, by using an immobilized antibody capture (IAC), to verify whether CMPs present on HIV-1 correlate with its host cell origin. HIV-1 grown in different cell lines incorporates cell markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the distinctive expression of these antigens on the host cells. Furthermore, also T-tropic and monocytotropic HIV-1 strains display host cell specific markers, supporting the hypothesis that virus associated CMPs are a marker of host cell origin.

Original languageEnglish
Pages (from-to)1849-1854
Number of pages6
JournalArchives of Virology
Volume140
Issue number10
DOIs
Publication statusPublished - Oct 1995

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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