Hot flushes in women with breast cancer: State of the art and future perspectives

Maddalena Barba, Laura Pizzuti, Domenico Sergi, Marcello Maugeri-Saccà, Cristina Vincenzoni, Francesca Conti, Federica Tomao, Enrico Vizza, Luigi Di Lauro, Franco Di Filippo, Silvia Carpano, Luciano Mariani, Patrizia Vici

Research output: Contribution to journalArticlepeer-review


Although not life-threatening, vasomotor symptoms might have a detrimental effect on quality of life and represent a major determinant of poor therapeutic compliance in breast cancer patients. Limitations of hormonal therapies have fostered the use of non-estrogenic pharmacological agents, which mainly include centrally acting compounds, antidepressant drugs, serotonin-norepinephrine reuptake inhibitors and serotonin reuptake inhibitors. Integrating therapeutic tools have recently come from a wide range of heterogeneous approaches varying from phytoestrogens use to ganglion block. We herein critically review the most updated evidence on the available treatment options for management of vasomotor symptoms. The need for a patient-oriented approach following systematic evaluation of the presence and degree of vasomotor disturbances is also discussed and future perspectives in therapeutics are summarized.

Original languageEnglish
Pages (from-to)185-198
Number of pages14
JournalExpert Review of Anticancer Therapy
Issue number2
Publication statusPublished - Feb 2014


  • breast cancer therapy
  • complementary and alternative medicine
  • hot flushes
  • non-hormonal therapy
  • vasomotor symptoms

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology


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