How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan

Pierachille Santus, Antonio Russo, Enzo Madonini, Luigi Allegra, Francesco Blasi, Stefano Centanni, Antonio Miadonna, Gianfranco Schiraldi, Sandro Amaducci

Research output: Contribution to journalArticlepeer-review


Background: Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy.Methods: We collected data from 45770 ERAs for respiratory diseases. A time-stratified case-crossover design was used to investigate the association between air pollution levels and ERAs for acute respiratory conditions. The effects of air pollutants were investigated at lag 0 to lag 5, lag 0-2 and lag 3-5 in both single and multi-pollutant models, adjusted for daily weather variables.Results: An increase in ozone (O3) levels at lag 3-5 was associated with a 78% increase in the number of ERAs for asthma, especially during the warm season. Exposure to carbon monoxide (CO) proved to be a risk factor for pneumonia at lag 0-2 and in the warm season increased the risk of ERA by 66%. A significant association was found between ERAs for COPD exacerbation and levels of sulphur dioxide (SO2), CO, nitrate dioxide (NO2), and particulate matter (PM10 and PM2.5). The multipollutant model that includes all pollutants showed a significant association between CO (26%) and ERA for upper respiratory tract diseases at lag 0-2. For chronic obstructive pulmonary disease (COPD) exacerbations, only CO (OR 1.19) showed a significant association.Conclusions: Exposure to environmental pollution, even at typical low levels, can increase the risk of ERA for acute respiratory diseases and exacerbation of obstructive lung diseases in the general population.

Original languageEnglish
Article number95
JournalRespiratory Research
Publication statusPublished - Oct 18 2012


  • Air pollution
  • Asthma
  • COPD
  • Emergency admissions
  • Public health

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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