How and when investigating and treating helicobacter pylori infection in children

Marco Manfredi, Federica Gaiani, Stefano Kayali, Barbara Bizzarri, Silvia Iuliano, Roberta Minelli, Gioacchino Leandro, Francesco Di Mario, Gian Luigi De’angelis

Research output: Contribution to journalReview articlepeer-review


For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Then, invasive tests i.e. gastroscopy are necessary to confirm the infection. As antibiotics are not widely available in children affected by Helicobacter pylori infection, they should be chosen based on individual antibiotic susceptibility testing obtained by gastric biopsy specimens or the local antibiotic resistance pattern, in empirical treatment is chosen. Test and treat strategy in children should be avoided. In this brief review we summarize how and in which children the infection should be investigate and which the most appropriate eradication treatment should be chosen. (

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalActa Biomedica
Publication statusPublished - Jan 1 2018


  • Antibiotic resistance
  • Antimicrobial susceptibility testing
  • Children
  • Esophagogastroduodenoscopy
  • Helicobacter pylori

ASJC Scopus subject areas

  • Medicine(all)


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