How ARDS should be treated

Luciano Gattinoni, Michael Quintel

Research output: Contribution to journalArticlepeer-review


The Berlin definition criteria applied at positive end-expiratory pressure (PEEP) 5 cm H2O reasonably predict lung edema and recruitabilty. To maintain viable gas exchange, the mechanical ventilation becomes progressively more risky going from mild to severe acute respiratory distress syndrome (ARDS). Tidal volume, driving pressure, flow, and respiratory rate have been identified as causes of ventilation-induced lung injury. Taken together, they represent the mechanical power applied to the lung parenchyma. In an inhomogeneous lung, stress risers locally increase the applied mechanical power. Increasing lung homogeneity by PEEP and prone position decreases the harm of mechanical ventilation, particularly in severe ARDS.

Original languageEnglish
Article number86
JournalCritical Care
Issue number1
Publication statusPublished - Apr 6 2016

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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