How best to control the lack of oxygen in the ischemic cardiomyocyte?

Filippo Crea, Gaetano Antonio Lanza

Research output: Contribution to journalArticle

Abstract

Continuous oxygen supply is crucial to cardiomyocyte function and integrity. Lack of oxygen leads to rapid myocardial cell damage. In the clinical setting, the most frequent cause of lack of oxygen in myocardial cells is ischemia. This may occur because: (i) coronary artery stenoses impede adequate increase in oxygen supply to match increased myocardial consumption; or (ii) a primary reduction in coronary blood flow (CBF) occurs resulting from acute coronary thrombosis or spasm. Definitive treatment of myocardial ischemia relies on prompt restoration of CBF. However, other treatments aim to increase the resistance of cardiomyocytes to ischemia and delay cell death in case of prolonged ischemia, through: (i) reduction in myocardial oxygen consumption; (ii) optimization of cardiomyocyte metabolism; (iii) preconditioning and postconditioning; or (iv) prevention of apoptoss.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalDialogues in Cardiovascular Medicine
Volume14
Issue number4
Publication statusPublished - 2009

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Keywords

  • β-blocker
  • Angiotensin receptor blocker
  • Apoptosis
  • Cardiomyocyte
  • Coronary blood flow
  • Glucose-insulin-potassium
  • Insulin-like growth factor I
  • Ivabradine
  • Myocardial ischemia
  • Oxygen supply
  • Perindopril
  • Postconditioning
  • Preconditioning
  • Ranolazine
  • Stenosis
  • Trimetazidine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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