How can we identify ictal and interictal abnormal activity?

Robert S. Fisher, Helen E. Scharfman, Marco DeCurtis

Research output: Chapter in Book/Report/Conference proceedingChapter

51 Citations (Scopus)

Abstract

The International League Against Epilepsy (ILAE) defined a seizure as "a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain." This definition has been used since the era of Hughlings Jackson, and does not take into account subsequent advances made in epilepsy and neuroscience research. The clinical diagnosis of a seizure is empirical, based upon constellations of certain signs and symptoms, while simultaneously ruling out a list of potential imitators of seizures. Seizures should be delimited in time, but the borders of ictal (during a seizure), interictal (between seizures) and postictal (after a seizure) often are indistinct. EEG recording is potentially very helpful for confirmation, classification and localization. About a half-dozen common EEG patterns are encountered during seizures. Clinicians rely on researchers to answer such questions as why seizures start, spread and stop, whether seizures involve increased synchrony, the extent to which extra-cortical structures are involved, and how to identify the seizure network and at what points interventions are likely to be helpful. Basic scientists have different challenges in use of the word 'seizure,' such as distinguishing seizures from normal behavior, which would seem easy but can be very difficult because some rodents have EEG activity during normal behavior that resembles spike-wave discharge or bursts of rhythmic spiking. It is also important to define when a seizure begins and stops so that seizures can be quantified accurately for pre-clinical studies. When asking what causes seizures, the transition to a seizure and differentiating the pre-ictal, ictal and post-ictal state is also important because what occurs before a seizure could be causal and may warrant further investigation for that reason. These and other issues are discussed by three epilepsy researchers with clinical and basic science expertise.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages3-23
Number of pages21
Volume813
ISBN (Print)9789401789134
DOIs
Publication statusPublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Electroencephalography
Seizures
Stroke
Brain
Epilepsy
Signs and Symptoms
Research Personnel
Neurosciences

Keywords

  • Behavioral arrest
  • Convulsion
  • Convulsive
  • Electroencephalogram
  • Epilepsy
  • Epileptic
  • Epileptiform
  • Focal seizure
  • Ictal
  • Interictal spike
  • Pre-ictal
  • Seizure-like
  • Sharp wave
  • Spike-wave discharge
  • Theta
  • Transition to seizure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Fisher, R. S., Scharfman, H. E., & DeCurtis, M. (2014). How can we identify ictal and interictal abnormal activity? In Advances in Experimental Medicine and Biology (Vol. 813, pp. 3-23). (Advances in Experimental Medicine and Biology; Vol. 813). Springer New York LLC. https://doi.org/10.1007/978-94-17-8914-1_1

How can we identify ictal and interictal abnormal activity? / Fisher, Robert S.; Scharfman, Helen E.; DeCurtis, Marco.

Advances in Experimental Medicine and Biology. Vol. 813 Springer New York LLC, 2014. p. 3-23 (Advances in Experimental Medicine and Biology; Vol. 813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fisher, RS, Scharfman, HE & DeCurtis, M 2014, How can we identify ictal and interictal abnormal activity? in Advances in Experimental Medicine and Biology. vol. 813, Advances in Experimental Medicine and Biology, vol. 813, Springer New York LLC, pp. 3-23. https://doi.org/10.1007/978-94-17-8914-1_1
Fisher RS, Scharfman HE, DeCurtis M. How can we identify ictal and interictal abnormal activity? In Advances in Experimental Medicine and Biology. Vol. 813. Springer New York LLC. 2014. p. 3-23. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-17-8914-1_1
Fisher, Robert S. ; Scharfman, Helen E. ; DeCurtis, Marco. / How can we identify ictal and interictal abnormal activity?. Advances in Experimental Medicine and Biology. Vol. 813 Springer New York LLC, 2014. pp. 3-23 (Advances in Experimental Medicine and Biology).
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