How complicated skin and soft tissue infections are treated in Italy: Economic evaluation of inpatient intravenous antibiotic treatment in seven hospitals

Rosanna Tarricone, Giovanni Aguzzi, Alessandro Capone, Carlo Maria Caravaggi, Silvano Esposito, Fabio Franzetti, Alba Muzzi, Lucia Ricci, Matteo Bassetti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Complicated skin and soft tissue infections (cSSTIs) are a common cause of morbidity at hospital level. This study aimed to evaluate the costs and outcomes of inpatient intravenous antibiotic therapy for the treatment of cSSTI in seven Italian hospitals. Methods: A total of 307 patients were enrolled in a retrospective, multicentre, incidence-based, observational study. The target population consisted of hospitalised patients eligible to receive intravenous antibiotic therapy for cSSTI. Direct hospital costs were measured through a microcosting approach. Results: Failure of initial antibiotic therapy occurred in 23% of patients. Average antibiotic treatment lasted 12.2 days; the average full cost of admission totalled €5,530. If the initial antibiotic regimen fails to eradicate the infectious organism, the length of stay extends for 7 days and costs increase by €2,850 per patient. Nevertheless, when taking into account the lower intensity of care during the last days of treatment, savings reduce costs to €671 per patient. These could be increased by €74 for each hospital day avoided because of faster antibiotic action. Conclusions: Efforts should be made to minimise the risk of selecting wrong antibiotics and to identify the quickest antibiotic in eradicating the infection.

Original languageEnglish
Pages (from-to)265-279
Number of pages15
JournalJournal of Medical Economics
Volume11
Issue number2
DOIs
Publication statusPublished - 2008

Keywords

  • Antibiotic treatment
  • cSSTI
  • Economic evaluation
  • Microcosting

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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