How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

Elena Ziviani, Alexander J. Whitworth

Research output: Contribution to journalShort surveypeer-review

Abstract

Much evidence links mitochondrial dysfunction to the death of neurons in Parkinson disease (PD), and is particularly emphasized by our growing understanding of the function of genes linked to recessively inherited PD such as PINK1, parkin and DJ-1. Recent work has revealed an exciting link between the PINK1-Parkin pathway and the autophagic turnover of dysfunctional mitochondrial (mitophagy). We have recently shown that mitofusin is ubiquitinated by Parkin when it is recruited to dysfunctional mitochondria. Recent work also shows that regulated fission and fusion events help segregate dysfunctional mitochondria prior to mitophagy. Here we hypothesize how Parkin-mediated ubiquitination of Mfn may play a role in this mechanism.

Original languageEnglish
Pages (from-to)660-662
Number of pages3
JournalAutophagy
Volume6
Issue number5
DOIs
Publication statusPublished - Jul 1 2010

Keywords

  • Drosophila
  • Mfn
  • Mitochondrial dynamics
  • Neurodegeneration
  • Parkin
  • Parkinson disease
  • PINK1
  • Ubiquitination

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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