How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies

Maarit Lehtovirta, Mikko P. Laakso, Giovanni B. Frisoni, Hilkka Soininen

Research output: Contribution to journalArticle

Abstract

The ε4 allele of apolipoprotein E is a risk factor for Alzheimer's disease, but also a modulator of its clinical picture. In this paper, recent research in neuroimaging of aging and Alzheimer's disease in relation to apolipoprotein E is reviewed, emphasizing the advances but also the controversies. Further, the possible clinicopathological implications of these findings are discussed. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)293-300
Number of pages8
JournalNeurobiology of Aging
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 2000

Keywords

  • Apolipoprotein E
  • Asymmetry
  • Dementia
  • Hippocampus
  • Magnetic resonance imaging
  • Positron emission tomography
  • Single photon emission Tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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