How frequent and how early does the neurological involvement in HIV-positive children occur? - Preliminary results of a prospective study

A. M. Laverda, P. Cogo, A. Condini, C. Cattelan, C. Giaquinto, S. Cozzani, E. Ruga, F. Viero, A. De Rossi, A. Del Mistro, L. Chieco Bianchi, F. Zacchello

Research output: Contribution to journalArticlepeer-review

Abstract

To study the natural history of the neurological involvement in pediatric human immunodeficiency virus (HIV) infection, 77 children born to seropositive mothers have been followed up since birth. The median follow-up time has been 17.5 months. Fourteen children were classified as infected, 34 as not infected, and 21 as indeterminable. Only two children with full-blown acute immune deficiency syndrome had severe neurological manifestations. "Soft" neurological signs were found in six infected, and ten non-infected children (χ2, P0.05). These data suggest that neurological and developmental abnormalities do not occur early in the course of vertical HIV infection and that they are associated with severe immunodeficiency.

Original languageEnglish
Pages (from-to)406-408
Number of pages3
JournalChild's Nervous System
Volume6
Issue number7
DOIs
Publication statusPublished - Nov 1990

Keywords

  • Children
  • HIV infection
  • Neurological manifestation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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