How I treat thrombotic thrombocytopenic purpura in pregnancy

Barbara Ferrari, Flora Peyvandi

Research output: Contribution to journalArticlepeer-review

Abstract

Thrombotic thrombocytopenic purpura (TTP) is an acute, life-threatening thrombotic microangiopathy (TMA) caused by acquired or congenital severe deficiency of ADAMTS13. Pregnancy is a recognized risk factor for precipitating acute (first or recurrent) episodes of TTP. Differential diagnosis with other TMAs is particularly difficult when the first TTP event occurs during pregnancy; a high index of suspicion and prompt recognition of TTP are essential for achievingagoodmaternal and fetal outcome. An accurate distinction between congenital and acquired cases of pregnancy-related TTP is mandatory for safe subsequent pregnancy planning. In this article, we summarize the current knowledge on pregnancy-associated TTP and describe how we manage TTP during pregnancy in our clinical practice.

Original languageEnglish
Pages (from-to)2125-2132
Number of pages8
JournalBlood
Volume136
Issue number19
DOIs
Publication statusPublished - Nov 5 2020

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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