How many patients need statin treatment in a low-cardiovascular-risk country? Low-density lipoprotein-cholesterol target and distance from target distribution in an Italian cohort

A. Poli, E. Tragni, M. Casula, A. Filippi, R. Diotti, O. Brignoli, C. Cricelli, A. L. Catapano, Aalders Maria Anna, Abbate Giuseppe, Agati Riccardo, Alano Raffaele, Alba Mauro, Alemagna Silvia, Alunni Massimo, Amato Fabio, Ammendola Erminia, Amodeo Vincenzo, Amoretti Giovanni, Andrani AlbertoAntiga Ivo, Appolonia Giorgio, Aramini Enrico, Arisi Marco Emilio, Artebani Adriano, Atzei Massimiliano, Azzolini Micheline, Bagagli Franco, Baldicchi Lorella, Banzi Roberta, Barba Ettore Maria, Barbato Pasquale Claudio, Barral Gino, Battaggia Alessandro, Battigelli Doriano, Baudi Marina, Bellumori Giovanni, Beltrami Giuseppe, Benincasa Anna Maria, Berardi Mario, Berlengiero Claudio, Bernardelli Stefano, Bernardi Giuseppe, Bertelle Evandro, Bettini Gianluca, Bevacqua Giuseppe, Bevilacqua Stefano, Bianconi Giuseppe, Biggioggero Giovanni, Bini Vincenzo, Bocchino Giancarlo, Boccone Nicolfranco, Boito Giancarlo, Bollo Alberto Maria, Boncompagni Salvatore, Bond Giuseppe, Bonesi Maria Grazia, Bono Gianfranco, Boscaro Federica, Bossi Paolo, Bozza Giulio, Bracone Enrico, Brandodoro Lucio, Brasesco Pierclaudio, Breviario Adele, Brizzi Antonio, Brugnetta Maurizio, Bruno Giuseppe, Buemi Giuseppe, Bufano Carmine, Bugli Tiziano, Burigo Daniela, Buzzatti Agostino, Caccamo Orazio Antonio, Cadamosti Danilo, Cagliesi Francesco, Caleffa Manuela, Cammisa Nicolo, Campo Franceso, Campobello Margherita, Caputo Stanislao, Caraccio Nicola, Cardi Silvio, Cardinale Fulvio, Caregnato Massimo, Cariola Gianni, Carlino Saverio, Carminati Luisa Angela, Carnelli Feliciano, Carnesalli Franco, Caruso Ciro, Casale Ezio, Casini Marcella, Cassanelli Marco, Castiello Maria Luisa, Castriotta Antonio, Catalano Domenico, Cataldi Maria Elvira, Ceccarini Agostino, Celebrano Mario, Celora Amedeo, Cerracchio Alessandro, Cesaro Andrea, Cesaro Federico, Chiriatti Alberto, Cipriani Rosa, Collura Giuseppe, Colombo Valter, Coluccia Salvatore, Corda Andrea, Cottani Antonio, Crivellenti Giuseppe, Dalla Rosa Rosanna, D'Ambrosio Gaetano, Damico Giansanto, D'Angelo Massimo, De Andreis Pier Luigi Bessone, De Benedictis Antonio, De Conto Umberto, De Mola Cosimo, De Rosa Antonio, De Tommasi Roberto, Del Nero Barbara, Della Briotta Ivana, Dell'Orco Mario Domenico, Dell'Orco Mario Lucio Raffaele, Di Candia Giuseppe, Di Carlo Vittorio, Di Febo Enrico, Di Feo Antonio, Di Fraia Giovanni, Di Fulvio Aristide, Di Nardo Dionisio, Dolmetta Franco, Donzelli Luigi, Dughiero Fausto, Durando Andrea, Ercolino Luigi, Fabbri Stelania, Fabrizio Nicola, Falchi Raffaello, Fariello Ciro, Fascendini Emilvio, Fasulo Serenella, Federici Laura, Ferioli Paolo, Ferrari Vincenzo, Filetti Giuseppe, Filippini Giovanni, Fogher Michele, Franchini Carlo Andrea, Frascati Angelo, Frignani Patrizia, Fronteddu Pier Francesco, Gadaleta Caldarola Gennaro, Galantini Giovanna, Gallicchio Nicola, Gallina Franco, Gallo Silvano, Gambino Fortunato, Gambuzza Guglielmo, Garaffa Elio, Garagiola Alberto, Garofalo Remigio, Garrone Alfonsino, Gatta Luigi, Gennari Massimo, Gerace Antonio, Geremia Maria Alessandra, Germini Fabrizio, Giacci Luciano, Giannini Olivia, Giordano Stefano, Giovannelli Umberto, Giuffré Giuseppe, Giunti Giuliana, Glaviano Bruno, Gorletta Giovanni, Grand Paola, Grassini Giovanni, Grasso Anna Maria, Grasso Maria Filomena, Grasso Giuseppe, Greco Agostino, Grifagni Marcello, Grilli Piero, Grimaldi Nicola, Grimaldi Emanuela, Grosso Marco, Guarnera Lucia, Guerra Antonio, Guillaro Bruno, Gussoni Barbara Rita, Ianiro Gabriella, Ilardi Salvatore, Imbalzano Pasquale, Inguscio Cherubino, Invernizzi Giovanni, Iocca Tommaso, Kos Egidia, La Mattina Rosolino, La Torre Angelo, Lacava Cosimo, Lalli Pasqualino, Lamera Giorgio, Lanza Gerardo, Lardo Gerardo, Laringe Matteo, Le Foche Luca, Leo Rosanna, Leuzzi Giacomo, Lipari Francesco, Lipari Antonino, Lippa Luciano, Lo Conte Maurizio, Lo Giudice Domenico, Lonati Rossella, Lorenzina Enrico, Magi Lorenzo, Magliozzo Francesco, Mallamo Luciano, Mantovani Licia, Marcenaro Alessandro, Marchetti Anna Rosa, Mariano Carlo, Marino Antonino, Mariuz Manuela, Maroni Achille, Martori Ampelio, Masoch Gigliola, Mattioli Mauro, Mattioli Carlo, Maurici Vincenzo, Mauro Nicola, Mazzardi Lidia, Mazzi Wainer, Mazzocchetti Alvaro, Mazzoleni Francesco, Mazzorana Michela, Medagliani Giorgio, Medea Gerardo, Merlino Giovanni, Merone Laura, Metrucci Antonio, Mezzano Silvio, Micchi Alessio, Micheli Pietro Severo, Milazzo Vito, Minafra Francesco, Minetti Luca, Mirandola Cipriano, Monari Gianluigi, Mongiello Claudio, Montano Giovanni, Montera Carmine, Moretti Marino, Morgana Ignazio, Morganti Mauro, Mormile Annunziata, Moro Roberto, Mostacciolo Francesco, Mourglia Danilo, Murari Tiziana, Muratore Alessandro, Murgia Rosalba, Naccari Massimo, Napoli Luigi, Nardacci Giuseppe, Nebiacolombo Cristina, Negri Fabrizio, Nicolini Gianfranco, Nigro Antonio, Noia Emanuela, Nuti Claudio Pietro, Olivani Enrico, Orlando Celestina, Padovan Letizia, Padula Maria Stella, Pagan Maurizio, Pannacci Valerio, Pantalone Vincenzo, Paolini Italo, Papandrea Giampaolo, Papulino Francesco, Paradisi Enza, Parisi Carmela, Parretti Damiano, Pasculli Domenico, Pasinelli Pietro Carlo, Pasqualetto Salvatore, Passamonti Marco, Passaro Vincenzo, Pederzani Fabio, Pedrazzoli Giuliano, Pelizzari Pier Carlo, Pernici Pierrenato, Pesaresi Carlo, Pesce Gian Luigi, Petrucci Mauro, Petrucci Marco, Petrulli Carmela, Petti Stefano, Piccinocchi Gaetano, Picciotto Rinaldo, Piccolo Francesco, Pierobon Ivo, Pilone Rita, Piva Roberto, Pizzillo Carlo, Plebani Franco, Polistina Stefano, Pontari Antonino, Poppi Maria Cristina, Portanti Carla, Prencipe Giovanni, Prestifilippo Alessandro, Procopio Antonio, Profeta Gaetano, Proietti Carlo, Quattrocchi Pietro, Raciti Teodoro, Ragazzoni Anna, Rattini Emanuela, Reale Emanuela, Redaelli Dario, Reggiani Claudio, Ricotta Giuseppe, Rigamonti Rodolfo, Righini Velella, Rinaldi Vanna, Rista Pierangela, Romano Salvatore, Romei Federico, Rossi Alberto, Rossi Gianluca, Rossi Francesco, Rossi Angelo, Rosso Lucia, Rovazzani Massimo, Rovelli Monica, Rovescala Pietroclaudio, Rubicini Giuseppe, Rubini Stefano, Ruggeri Mauro, Russo Vincenzo, Russo Carolina, Sala Massimo, Salurso Daniele, Salvaderi Maria Dionice, Salvato Alberto, Salvetti Andrea, Salvio Giuliano, Samani Fabio, Sammarco Renato, Santoiemma Luigi, Santoro Michele, Sassarini Graziano, Savino Andrea, Scaglione Matteo, Scarano Libero, Schiavone Ciro, Scola Vincenzo, Scorpiniti Anna, Scotto D Antuono Antonio, Scovotto Mari Antonietta, Scuri Maurizio Giovanni, Scuteri Antonio, Sebastianelli Giuliano, Sebben Maurizio, Sforza Pasqualino, Sfragara Ignazio, Sicari Giuseppe, Simonini Giorgio, Soldani Miriam, Soverina Patrizio, Spagnolo Beatrice, Sperandio Massimo, Spezzano Alfredo, Steri Lia, Storni Paolo, Strada Sonia, Stramenga Carlo, Tagliabue Paola Fausta, Tarabini Legnoaura, Tarallo Nicola, Tei Alessandro, Tei Gian Paolo, Testi Sergio, Testolin Ennio, Tibo Angela, Titone Nicolò, Tomasello Antonino, Tondi Lidia, Torti Giorgio Tommaso, Toscano Emanuele, Tota Maria Fiorenza, Tozzoli Alfonso, Travaglini Rita, Trois Paolo, Trotta Gaetano, Tuia Bruno, Turbil Enrico, Ughetti Claudio, Urru Cesare, Valente Fabio, Valenti Marco, Valle Lucia, Valletta Domenico, Valore Salvatore, Valvedit Maria, Varriale Antonio, Varrica Gaetano, Ventriglia Giuseppe, Venturelli Antonio, Vesco Giuseppe, Vezzosi Angelo, Viola Dario, Viscusi Bruno, Vita Salvatore, Vitali Franco, Vittozzi Dante Sergio, Vivona Giacomo, Volpe Augusto, Volpone Damiano Antonio, Voza Italo, Zadra Alessandro, Zaninetti Piero, Zanini Riccardo, Zennaro Walter, Zingaro Angelo, Zito Alfonso, Zollino Luciana, Zovi Maria Carla, Zunino Roberto

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aim: To assess cardiovascular risk distribution, distribution of individual low-density lipoprotein (LDL)-cholesterol target and distance of LDL cholesterol from the target in a representative sample of the Italian population. Methods and results: Cross-sectional, population-based study of a representative sample of the Italian adult population, comprising 5458 individuals (from 40 to 79 years of age, both sexes) from general practices in Italy.Of the subjects, 65.2% were in the low-cardiovascular-risk class, whereas 10.5%, 18.3% and 6.0% had moderate, high, and very high cardiovascular risk profiles, respectively; 8.2% of the subjects were treated with statins at enrolment. Of the cohort, 68.3% displayed LDL-cholesterol values below their LDL target, as calculated according to their individual risk profile. Among the 31.7% 'not at target', 42.3% were ≤15%, 44.3% were between 15% and 40% and 13.4% were >40% over their LDL target. Conclusions: About two-thirds of adults in a low-cardiovascular-risk country, such as Italy, have LDL-cholesterol levels 'at target', as defined in current guidelines. Accordingly, the remaining subjects require a lifestyle or pharmacological intervention to reach their target; 24% of the total cohort, in detail, need to be treated with a statin (or to continue the prescribed statin treatment) to reach the proper LDL target. This type of data analysis might help to optimise resource allocation in preventive medicine.

Original languageEnglish
Pages (from-to)327-336
Number of pages10
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Distance from target
  • Global cardiovascular risk
  • LDL target
  • Population studies
  • Statin use

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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