Abstract
Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.
| Original language | English |
|---|---|
| Journal | Trends in Microbiology |
| DOIs | |
| Publication status | Accepted/In press - 2016 |
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Keywords
- Epigenetics
- Exosomes
- Gut microbiota
- Non-coding RNAs
- Outer-membrane vesicles
ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
- Microbiology
- Virology
Cite this
How Our Other Genome Controls Our Epi-Genome. / Celluzzi, Antonella; Masotti, Andrea.
In: Trends in Microbiology, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How Our Other Genome Controls Our Epi-Genome
AU - Celluzzi, Antonella
AU - Masotti, Andrea
PY - 2016
Y1 - 2016
N2 - Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.
AB - Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.
KW - Epigenetics
KW - Exosomes
KW - Gut microbiota
KW - Non-coding RNAs
KW - Outer-membrane vesicles
UR - http://www.scopus.com/inward/record.url?scp=84973546892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973546892&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2016.05.005
DO - 10.1016/j.tim.2016.05.005
M3 - Article
AN - SCOPUS:84973546892
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
ER -