How Our Other Genome Controls Our Epi-Genome

Antonella Celluzzi, Andrea Masotti

Research output: Contribution to journalArticle

Abstract

Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.

Original languageEnglish
JournalTrends in Microbiology
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Genome
Membranes
Human Genome
MicroRNAs
Histone Code
Bacterial RNA
Long Noncoding RNA
RNA
Bacteria
Eukaryota
Social Support
Communication
Escherichia coli
Pharmaceutical Preparations
Neoplasms
Therapeutics

Keywords

  • Epigenetics
  • Exosomes
  • Gut microbiota
  • Non-coding RNAs
  • Outer-membrane vesicles

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

How Our Other Genome Controls Our Epi-Genome. / Celluzzi, Antonella; Masotti, Andrea.

In: Trends in Microbiology, 2016.

Research output: Contribution to journalArticle

@article{84ce18afda7e4343a76d93de205fdf39,
title = "How Our Other Genome Controls Our Epi-Genome",
abstract = "Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.",
keywords = "Epigenetics, Exosomes, Gut microbiota, Non-coding RNAs, Outer-membrane vesicles",
author = "Antonella Celluzzi and Andrea Masotti",
year = "2016",
doi = "10.1016/j.tim.2016.05.005",
language = "English",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - How Our Other Genome Controls Our Epi-Genome

AU - Celluzzi, Antonella

AU - Masotti, Andrea

PY - 2016

Y1 - 2016

N2 - Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.

AB - Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us. The first evidence that outer-membrane vesicles (OMVs) are produced by Escherichia coli dates from 1976. After 40 years, bioengineered OMVs are considered today to be promising innovative vectors for drug delivery and cancer therapy.The first evidence of inter-kingdom crosstalk between humans and gut microbiota through microRNAs that are contained in extracellular vesicles (EVs) was reported earlier this year.Many bacterial small RNAs that are contained in OMVs align to histone marks in the human genome. We hypothesized that they may act as long non-coding RNAs, thus regulating our epigenome.We still do not know how many diseases or pathological conditions may be caused by the interplay between bacterial OMVs and the human genome.

KW - Epigenetics

KW - Exosomes

KW - Gut microbiota

KW - Non-coding RNAs

KW - Outer-membrane vesicles

UR - http://www.scopus.com/inward/record.url?scp=84973546892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973546892&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2016.05.005

DO - 10.1016/j.tim.2016.05.005

M3 - Article

AN - SCOPUS:84973546892

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

ER -