TY - JOUR
T1 - How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment
AU - De Gregori, Simona
AU - Niebel, Thekla
AU - Minella, Cristina E.
AU - Allegri, Massimo
AU - Regazzi, Mario
PY - 2011/11
Y1 - 2011/11
N2 - Opioids are widely used in treatment of acute and chronic pain patients, and today a lot of efforts are put into individualize these therapies. Physicians would like to reduce deaths, minimize side effects and prevent toxicity, but - nevertheless PCA could represent a solution - up to date it is not yet completely reliable. A sustaining pharmacokinetic approach gives significant contribution, in particular in treatment of special populations (e.g. infants, elderly, and patients with renal/liver failure), which have a unique opioids pharmacokinetic profile to be taken into account, in order to maximize analgesic efficacy and reduce the risk of adverse events.
AB - Opioids are widely used in treatment of acute and chronic pain patients, and today a lot of efforts are put into individualize these therapies. Physicians would like to reduce deaths, minimize side effects and prevent toxicity, but - nevertheless PCA could represent a solution - up to date it is not yet completely reliable. A sustaining pharmacokinetic approach gives significant contribution, in particular in treatment of special populations (e.g. infants, elderly, and patients with renal/liver failure), which have a unique opioids pharmacokinetic profile to be taken into account, in order to maximize analgesic efficacy and reduce the risk of adverse events.
KW - Fentanyl
KW - Morphine
KW - PCA
KW - Pharmacokinetics
KW - Renal and liver failure
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U2 - 10.1016/j.eujps.2011.08.020
DO - 10.1016/j.eujps.2011.08.020
M3 - Article
AN - SCOPUS:83355160642
VL - 5
SP - 477
EP - 483
JO - European Journal of Pain Supplements
JF - European Journal of Pain Supplements
SN - 1754-3207
IS - 2
ER -