How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment

Simona De Gregori, Thekla Niebel, Cristina E. Minella, Massimo Allegri, Mario Regazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Opioids are widely used in treatment of acute and chronic pain patients, and today a lot of efforts are put into individualize these therapies. Physicians would like to reduce deaths, minimize side effects and prevent toxicity, but - nevertheless PCA could represent a solution - up to date it is not yet completely reliable. A sustaining pharmacokinetic approach gives significant contribution, in particular in treatment of special populations (e.g. infants, elderly, and patients with renal/liver failure), which have a unique opioids pharmacokinetic profile to be taken into account, in order to maximize analgesic efficacy and reduce the risk of adverse events.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalEuropean Journal of Pain Supplements
Volume5
Issue number2
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Fentanyl
  • Morphine
  • PCA
  • Pharmacokinetics
  • Renal and liver failure

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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