How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment

Simona De Gregori; Thekla Niebel; Cristina E. Minella; Massimo Allegri; Mario Regazzi

doi:10.1016/j.eujps.2011.08.020

How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment

Simona De Gregori, Thekla Niebel, Cristina E. Minella, Massimo Allegri, Mario Regazzi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Opioids are widely used in treatment of acute and chronic pain patients, and today a lot of efforts are put into individualize these therapies. Physicians would like to reduce deaths, minimize side effects and prevent toxicity, but - nevertheless PCA could represent a solution - up to date it is not yet completely reliable. A sustaining pharmacokinetic approach gives significant contribution, in particular in treatment of special populations (e.g. infants, elderly, and patients with renal/liver failure), which have a unique opioids pharmacokinetic profile to be taken into account, in order to maximize analgesic efficacy and reduce the risk of adverse events.

Original language	English
Pages (from-to)	477-483
Number of pages	7
Journal	European Journal of Pain Supplements
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.eujps.2011.08.020
Publication status	Published - Nov 2011

Keywords

Fentanyl
Morphine
PCA
Pharmacokinetics
Renal and liver failure

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.eujps.2011.08.020

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Cite this

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title = "How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment",

abstract = "Opioids are widely used in treatment of acute and chronic pain patients, and today a lot of efforts are put into individualize these therapies. Physicians would like to reduce deaths, minimize side effects and prevent toxicity, but - nevertheless PCA could represent a solution - up to date it is not yet completely reliable. A sustaining pharmacokinetic approach gives significant contribution, in particular in treatment of special populations (e.g. infants, elderly, and patients with renal/liver failure), which have a unique opioids pharmacokinetic profile to be taken into account, in order to maximize analgesic efficacy and reduce the risk of adverse events.",

keywords = "Fentanyl, Morphine, PCA, Pharmacokinetics, Renal and liver failure",

author = "{De Gregori}, Simona and Thekla Niebel and Minella, {Cristina E.} and Massimo Allegri and Mario Regazzi",

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AU - Regazzi, Mario

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KW - Pharmacokinetics

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