How tails guide tail-anchored proteins to their destinations

Nica Borgese, Silvia Brambillasca, Sara Colombo

Research output: Contribution to journalReview articlepeer-review

Abstract

A large group of diverse, functionally important, and differently localized transmembrane proteins shares a particular membrane topology, consisting of a cytosolic N-terminal region, followed by a transmembrane domain close to the C-terminus. Because of their structure, these C-tail-anchored (TA) proteins must insert into all their target membranes by post-translational pathways. Recent work, based on the development of stringent and sensitive biochemical assays, has demonstrated that novel unexplored mechanisms underlie these post-translational targeting and membrane insertion pathways. Unravelling these pathways will shed light on the biosynthesis and regulation of an important group of membrane proteins and is likely to lead to new concepts in the field of membrane biogenesis.

Original languageEnglish
Pages (from-to)368-375
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Cell Biology

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