TY - JOUR
T1 - How the interplay between antigen presenting cells and microbiota tunes host immune responses in the gut
AU - Swiatczak, Bartlomiej
AU - Rescigno, Maria
PY - 2012/2
Y1 - 2012/2
N2 - Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation.
AB - Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation.
KW - Anti{dotless}gen-presenti{dotless}ng cells
KW - Dendritic cells
KW - Microbiota
KW - Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84857042278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857042278&partnerID=8YFLogxK
U2 - 10.1016/j.smim.2011.11.004
DO - 10.1016/j.smim.2011.11.004
M3 - Article
C2 - 22137188
AN - SCOPUS:84857042278
VL - 24
SP - 43
EP - 49
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 1
ER -