How the interplay between antigen presenting cells and microbiota tunes host immune responses in the gut

Bartlomiej Swiatczak, Maria Rescigno

Research output: Contribution to journalArticlepeer-review

Abstract

Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalSeminars in Immunology
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Anti{dotless}gen-presenti{dotless}ng cells
  • Dendritic cells
  • Microbiota
  • Microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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