How the interplay between the commensal microbiota, gut barrier integrity, and mucosal immunity regulates brain autoimmunity

Martina Antonini, Marta Lo Conte, Chiara Sorini, Marika Falcone

Research output: Contribution to journalReview articlepeer-review

Abstract

The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance in both intestinal microbiota composition and mucosal immunity activation, along with an alteration of gut barrier permeability, suggesting this complex network plays a crucial role in modulating the course of autoimmune responses occurring in tissues outside the gut such as the central nervous system (CNS). Here, we review current knowledge on how gut inflammation and breakage of gut barrier integrity modulates the interplay between the commensal gut microbiota and the immune system and its role in shaping brain immunity.

Original languageEnglish
Article number1937
JournalFrontiers in Immunology
Volume10
Issue numberAUG
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Autoimminity
  • Central nervous system
  • Gut barrier
  • Microbiota
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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