How to build a glycinergic postsynaptic membrane

H. Betz, J. Kuhse, V. Schmieden, M. L. Malosio, D. Langosch, P. Prior, B. Schmitt, J. Kirsch

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The inhibitory glycine receptor (GlyR) is a ligandgated chloride channel protein found at many synapses of the mammalian central nervous system. During development, distinct isoforms of the GlyR are generated by the sequential expression of different α subunit variants. The appearance of adult type GlyRs in spinal cord is accompanied by the accumulation of a 93 x 103M(r) receptor-associated peripheral membrane protein. The latter has been localized at the cytoplasmic face of glycinergic postsynaptic membranes and is thought to anchor GlyRs beneath glycinergic nerve terminals. The 93 x 103M(r) protein binds with high affinity to polymerized tubulin, suggesting that it functions as a receptor-micro tubule linking component. Our data suggest that the interaction of developmentally regulated receptor isoforms with specialized microtubule-associated proteins represents a crucial step in the assembly of postsynaptic receptor matrices.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalJournal of Cell Science
Volume100
Issue numberSUPPL. 15
Publication statusPublished - 1991

Fingerprint

Glycine Receptors
Protein Isoforms
Chloride Channels
Microtubule-Associated Proteins
Membranes
Tubulin
Synapses
Spinal Cord
Membrane Proteins
Proteins
Central Nervous System

Keywords

  • Glycine receptor
  • Postsynaptic inhibition
  • Receptor isoforms
  • Receptor-associated proteins

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Betz, H., Kuhse, J., Schmieden, V., Malosio, M. L., Langosch, D., Prior, P., ... Kirsch, J. (1991). How to build a glycinergic postsynaptic membrane. Journal of Cell Science, 100(SUPPL. 15), 23-25.

How to build a glycinergic postsynaptic membrane. / Betz, H.; Kuhse, J.; Schmieden, V.; Malosio, M. L.; Langosch, D.; Prior, P.; Schmitt, B.; Kirsch, J.

In: Journal of Cell Science, Vol. 100, No. SUPPL. 15, 1991, p. 23-25.

Research output: Contribution to journalArticle

Betz, H, Kuhse, J, Schmieden, V, Malosio, ML, Langosch, D, Prior, P, Schmitt, B & Kirsch, J 1991, 'How to build a glycinergic postsynaptic membrane', Journal of Cell Science, vol. 100, no. SUPPL. 15, pp. 23-25.
Betz H, Kuhse J, Schmieden V, Malosio ML, Langosch D, Prior P et al. How to build a glycinergic postsynaptic membrane. Journal of Cell Science. 1991;100(SUPPL. 15):23-25.
Betz, H. ; Kuhse, J. ; Schmieden, V. ; Malosio, M. L. ; Langosch, D. ; Prior, P. ; Schmitt, B. ; Kirsch, J. / How to build a glycinergic postsynaptic membrane. In: Journal of Cell Science. 1991 ; Vol. 100, No. SUPPL. 15. pp. 23-25.
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