How to build a glycinergic postsynaptic membrane

H. Betz, J. Kuhse, V. Schmieden, M. L. Malosio, D. Langosch, P. Prior, B. Schmitt, J. Kirsch

Research output: Contribution to journalArticlepeer-review

Abstract

The inhibitory glycine receptor (GlyR) is a ligandgated chloride channel protein found at many synapses of the mammalian central nervous system. During development, distinct isoforms of the GlyR are generated by the sequential expression of different α subunit variants. The appearance of adult type GlyRs in spinal cord is accompanied by the accumulation of a 93 x 103M(r) receptor-associated peripheral membrane protein. The latter has been localized at the cytoplasmic face of glycinergic postsynaptic membranes and is thought to anchor GlyRs beneath glycinergic nerve terminals. The 93 x 103M(r) protein binds with high affinity to polymerized tubulin, suggesting that it functions as a receptor-micro tubule linking component. Our data suggest that the interaction of developmentally regulated receptor isoforms with specialized microtubule-associated proteins represents a crucial step in the assembly of postsynaptic receptor matrices.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalJournal of Cell Science
Volume100
Issue numberSUPPL. 15
Publication statusPublished - 1991

Keywords

  • Glycine receptor
  • Postsynaptic inhibition
  • Receptor isoforms
  • Receptor-associated proteins

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

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