How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics

Pasquale Patrizio, Alberto Vaiarelli, Paolo E. Levi Setti, Kyle J. Tobler, Gon Shoham, Milton Leong, Zeev Shoham

Research output: Contribution to journalArticlepeer-review


Poor responders represent a significant percentage of couples treated in IVF units (10-24%), but the standard definition of poor responders remains uncertain and consequently optimal treatment options remain subjective and not evidence-based. In an attempt to provide uniformity on the definition, diagnosis and treatment of poor responders, a worldwide survey was conducted asking IVF professionals a set of questions on this complex topic. The survey was posted on, the largest and most comprehensive IVF-focused website for physicians and embryologists. A total of 196 centres replied, forming a panel of IVF units with a median of 400 cycles per year. The present study shows that the definition of poor responders is still subjective, and many practices do not use evidence-based treatment for this category of patients. Our hope is that by leveraging the great potential of the internet, future studies may provide immediate large-scale sampling to standardize both poor responder definition and treatment options.

Original languageEnglish
Pages (from-to)581-592
Number of pages12
JournalReproductive BioMedicine Online
Issue number6
Publication statusPublished - Jun 1 2015


  • decreased ovarian function
  • IVF
  • management
  • ovarian stimulation
  • poor responder
  • survey

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology


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