How to manage children who have come into contact with patients affected by tuberculosis

Laura Lancella, Andrea Lo Vecchio, Elena Chiappini, Marina Tadolini, Daniela Cirillo, Enrico Tortoli, Maurizio de Martino, Alfredo Guarino, Nicola Principi, Alberto Villani, Susanna Esposito, Luisa Galli, Laura Cursi, Annalisa Grandin, Caterina Marabotto, Riccardo Scotto, Carlotta Montagnani, Daniele Ciofi, Filippo Festini, Martina AnziatiSabrina Becciani, Giulia Remaschi, Sara Sollai, Chiara Tersigni, Elisabetta Venturini, Cristina Russo, Samantha Bosis, Claudia Tagliabue, Laura Senatore, Beatrice Ascolese, Filippo Bernardi, Elisa Bertazzoni, Francesco Blasi, Marialuisa Bocchino, Luca Assante, Elio Castagnola, Giuseppe Losurdo, Luigi Codecasa, Giuseppe Di Mauro, Marino Faccini, Clara Gabiano, Silvia Garazzino, Daniele Le Serre, Irene Raffaldi, Gianluigi Marseglia, Amelia Mascolo, Amelia Di Comite, Mauro Stronati, Alberto Matteelli, Giovanni Battista Migliori, Rossella Centis, Lia D'Ambrosio, Angela Pasinato, Franco Scaglione, Elisabetta Scala, Paolo Tomà

Research output: Contribution to journalArticle

Abstract

Childhood tuberculosis (TB) indicates a recent infection, particularly in children aged <5 years, and therefore is considered a sentinel event insofar as it highlights the presence of an undiagnosed or untreated source case. The risk of acquiring TB is directly proportional to the number of bacilli to which a subject is exposed and the environment in which the contact occurred. This document contains the recommendations of a group of Italian scientific societies for managing a child exposed to a case of TB based on an analysis of the risk factors for acquiring latent tuberculous infection (LTBI) and developing the disease, and the particular aspects TB transmission during the first years of life. The guidance includes a detailed description of the methods used to identify the index case, the tests that the exposed child should receive and the possibilities of preventive chemoprophylaxis depending on the patient's age and immune status, the chemotherapy and monitoring methods indicated in the case of LTBI, the management of a child who has come into contact with a case of multidrug-resistant or extensively drug-resistant TB, and the use of molecular typing in the analysis of epidemics. The group of experts identified risk factors for tuberculous infection and disease in pediatric age as well as gave recommendation on management of contacts of cases of TB according to their age, risk factors and exposure to multidrug-resistant or extensively drug-resistant TB.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
Volume1
DOIs
Publication statusPublished - Nov 1 2015

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Keywords

  • Contacts
  • IGRA
  • LTBI
  • Multidrug-resistant tuberculosis
  • Mycobacterium tuberculosis
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Lancella, L., Vecchio, A. L., Chiappini, E., Tadolini, M., Cirillo, D., Tortoli, E., de Martino, M., Guarino, A., Principi, N., Villani, A., Esposito, S., Galli, L., Cursi, L., Grandin, A., Marabotto, C., Scotto, R., Montagnani, C., Ciofi, D., Festini, F., ... Tomà, P. (2015). How to manage children who have come into contact with patients affected by tuberculosis. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 1, 1-12. https://doi.org/10.1016/j.jctube.2015.07.002