How to Manage Electrical Status Epilepticus in Sleep

Pierangelo Veggiotti, Maria Carmela Pera, Sara Olivotto, Valentina De Giorgis

Research output: Contribution to journalArticlepeer-review


Summary: Electrical status epilepticus in sleep is an age-dependent syndrome with the characteristic pattern of continuous spike and waves during non-rapid eye movement sleep. Most children can present developmental deterioration. The demonstration of the EEG pattern has to rely on all night long EEG recordings. A comprehensive neuropsychologic evaluation with periodic reassessment should be performed. For the idiopathic forms of electrical status epilepticus in sleep, clobazam could be considered as the first-line therapy; in the other cases, corticosteroids, in particular intravenous methylprednisolone pulse therapy, remain the most effective and should be considered the therapy of choice.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalJournal of Clinical Neurophysiology
Issue number1
Publication statusPublished - Feb 1 2016


  • Clobazam
  • E-SES
  • Methylprednisolone
  • Neuropsychologic assessment
  • Spike-wave index

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology
  • Physiology (medical)


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