How to RESPOND to modern challenges for people living with HIV: A profile for a new cohort consortium

AIDS Therapy Evaluation in the Netherlands Cohort (ATHENA), The Australian HIV Observational Database (AHOD), Austrian HIV Cohort Study (AHIVCOS), CHU Saint-Pierre, EuroSIDA Cohort, Infectious Diseases, AIDS and Clinical Immunology Research Center (IDACIRC), Italian Cohort Naive Antiretrovirals (ICONA), Modena HIV Cohort, Nice HIV Cohort, PISCIS Cohort Study, The RESPOND study group

Research output: Contribution to journalArticlepeer-review

Abstract

Background: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases. Methods: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12. Results: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40–56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8–17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438–830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events. Conclusion: RESPOND’s large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.

Original languageEnglish
Article number1164
Pages (from-to)1-17
Number of pages17
JournalMicroorganisms
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Cohort
  • Hepatitis
  • HIV
  • Observational study
  • Pharmacovigilance
  • Public health
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Virology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'How to RESPOND to modern challenges for people living with HIV: A profile for a new cohort consortium'. Together they form a unique fingerprint.

Cite this