How to study coronary microvascular dysfunction and its clinical relevance

Antonio L'Abbate, Gianmario Sambuceti

Research output: Contribution to journalArticle

Abstract

It is now accepted that the precipitation of acute coronary syndromes and, mostly, of acute myocardial infarction often occurs in patients who do not show critical stenoses. This and other findings challenge the relevance of stenosis severity as a major pathogenetic determinant in ischemic heart disease. Thus, a large amount of research has been put forward to investigate further mechanisms, besides changes in plaque burden and stenosis severity, associated with the precipitation of ischemia. Among putative mechanisms, great attention has been paid in the last decades to the activation of the atherosclerotic plaque and its complications, while only recently the interest has been focused on the potential role of coronary microcirculation as a cofactor in many clinical manifestations of ischemic heart disease. At present, the clinical evaluation of coronary microcirculation is hampered by a number of methodological limitations while the experimental models of coronary atherosclerosis and ischemic heart disease are still far from being satisfactory. As a consequence, although an involvement of the coronary microcirculation has been suspected in a large number of clinical syndromes, its nature and mechanisms still remain largely speculative. The present paper will try to critically review theoretical and technical approaches to the study of coronary microcirculation in ischemic heart disease with the aim at providing the reader with those elements potentially helpful to his own judgment on the matter.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalItalian Heart Journal
Volume3
Issue number4
Publication statusPublished - 2002

Fingerprint

Microcirculation
Myocardial Ischemia
Pathologic Constriction
Atherosclerotic Plaques
Acute Coronary Syndrome
Coronary Disease
Coronary Artery Disease
Theoretical Models
Ischemia
Myocardial Infarction
Research

Keywords

  • Coronary microcirculation
  • Coronary stenosis
  • Myocardial ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

How to study coronary microvascular dysfunction and its clinical relevance. / L'Abbate, Antonio; Sambuceti, Gianmario.

In: Italian Heart Journal, Vol. 3, No. 4, 2002, p. 230-236.

Research output: Contribution to journalArticle

@article{7bbebc996bad476b8b512403b2ae6961,
title = "How to study coronary microvascular dysfunction and its clinical relevance",
abstract = "It is now accepted that the precipitation of acute coronary syndromes and, mostly, of acute myocardial infarction often occurs in patients who do not show critical stenoses. This and other findings challenge the relevance of stenosis severity as a major pathogenetic determinant in ischemic heart disease. Thus, a large amount of research has been put forward to investigate further mechanisms, besides changes in plaque burden and stenosis severity, associated with the precipitation of ischemia. Among putative mechanisms, great attention has been paid in the last decades to the activation of the atherosclerotic plaque and its complications, while only recently the interest has been focused on the potential role of coronary microcirculation as a cofactor in many clinical manifestations of ischemic heart disease. At present, the clinical evaluation of coronary microcirculation is hampered by a number of methodological limitations while the experimental models of coronary atherosclerosis and ischemic heart disease are still far from being satisfactory. As a consequence, although an involvement of the coronary microcirculation has been suspected in a large number of clinical syndromes, its nature and mechanisms still remain largely speculative. The present paper will try to critically review theoretical and technical approaches to the study of coronary microcirculation in ischemic heart disease with the aim at providing the reader with those elements potentially helpful to his own judgment on the matter.",
keywords = "Coronary microcirculation, Coronary stenosis, Myocardial ischemia",
author = "Antonio L'Abbate and Gianmario Sambuceti",
year = "2002",
language = "English",
volume = "3",
pages = "230--236",
journal = "Italian Heart Journal",
issn = "1129-471X",
publisher = "Societa Italiana di Cardiologia",
number = "4",

}

TY - JOUR

T1 - How to study coronary microvascular dysfunction and its clinical relevance

AU - L'Abbate, Antonio

AU - Sambuceti, Gianmario

PY - 2002

Y1 - 2002

N2 - It is now accepted that the precipitation of acute coronary syndromes and, mostly, of acute myocardial infarction often occurs in patients who do not show critical stenoses. This and other findings challenge the relevance of stenosis severity as a major pathogenetic determinant in ischemic heart disease. Thus, a large amount of research has been put forward to investigate further mechanisms, besides changes in plaque burden and stenosis severity, associated with the precipitation of ischemia. Among putative mechanisms, great attention has been paid in the last decades to the activation of the atherosclerotic plaque and its complications, while only recently the interest has been focused on the potential role of coronary microcirculation as a cofactor in many clinical manifestations of ischemic heart disease. At present, the clinical evaluation of coronary microcirculation is hampered by a number of methodological limitations while the experimental models of coronary atherosclerosis and ischemic heart disease are still far from being satisfactory. As a consequence, although an involvement of the coronary microcirculation has been suspected in a large number of clinical syndromes, its nature and mechanisms still remain largely speculative. The present paper will try to critically review theoretical and technical approaches to the study of coronary microcirculation in ischemic heart disease with the aim at providing the reader with those elements potentially helpful to his own judgment on the matter.

AB - It is now accepted that the precipitation of acute coronary syndromes and, mostly, of acute myocardial infarction often occurs in patients who do not show critical stenoses. This and other findings challenge the relevance of stenosis severity as a major pathogenetic determinant in ischemic heart disease. Thus, a large amount of research has been put forward to investigate further mechanisms, besides changes in plaque burden and stenosis severity, associated with the precipitation of ischemia. Among putative mechanisms, great attention has been paid in the last decades to the activation of the atherosclerotic plaque and its complications, while only recently the interest has been focused on the potential role of coronary microcirculation as a cofactor in many clinical manifestations of ischemic heart disease. At present, the clinical evaluation of coronary microcirculation is hampered by a number of methodological limitations while the experimental models of coronary atherosclerosis and ischemic heart disease are still far from being satisfactory. As a consequence, although an involvement of the coronary microcirculation has been suspected in a large number of clinical syndromes, its nature and mechanisms still remain largely speculative. The present paper will try to critically review theoretical and technical approaches to the study of coronary microcirculation in ischemic heart disease with the aim at providing the reader with those elements potentially helpful to his own judgment on the matter.

KW - Coronary microcirculation

KW - Coronary stenosis

KW - Myocardial ischemia

UR - http://www.scopus.com/inward/record.url?scp=0036019176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036019176&partnerID=8YFLogxK

M3 - Article

C2 - 12025371

AN - SCOPUS:0036019176

VL - 3

SP - 230

EP - 236

JO - Italian Heart Journal

JF - Italian Heart Journal

SN - 1129-471X

IS - 4

ER -