HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1

A. Puliti, R. Cinti, N. Betsos, G. Romeo, Isabella Ceccherini

Research output: Contribution to journalArticle

Abstract

HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1→p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3-D1 and human 2p13.1→p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX11L1 (Tlx2).

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalCytogenetics and Cell Genetics
Volume84
Issue number1-2
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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