Abstract
Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Infezioni in Medicina |
| Volume | 26 |
| Issue number | 2 |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Chlamydia trachomatis
- Genotyping
- HPV
- Paptest
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
HPV and chlamydia trachomatis coinfection in women with pap smear abnormality : Baseline data of the HPV pathogen ISS study. / Mancini, Fabiola; Vescio, Fenicia; Mochi, Stefania; Accardi, Luisa; Di Bonito, Paola; Ciervo, Alessandra.
In: Infezioni in Medicina, Vol. 26, No. 2, 01.01.2018, p. 139-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HPV and chlamydia trachomatis coinfection in women with pap smear abnormality
T2 - Baseline data of the HPV pathogen ISS study
AU - Mancini, Fabiola
AU - Vescio, Fenicia
AU - Mochi, Stefania
AU - Accardi, Luisa
AU - Di Bonito, Paola
AU - Ciervo, Alessandra
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.
AB - Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.
KW - Chlamydia trachomatis
KW - Genotyping
KW - HPV
KW - Paptest
UR - http://www.scopus.com/inward/record.url?scp=85054308258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054308258&partnerID=8YFLogxK
M3 - Article
VL - 26
SP - 139
EP - 144
JO - Infezioni in Medicina
JF - Infezioni in Medicina
SN - 1124-9390
IS - 2
ER -