HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality

baseline data of the HPV Pathogen ISS study

Research output: Contribution to journalArticle

Abstract

Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalLe infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
Volume26
Issue number2
Publication statusPublished - Jun 1 2018

Fingerprint

Papanicolaou Test
Chlamydia trachomatis
Coinfection
Papillomavirus Infections
Uterine Cervical Neoplasms
Genotype
Chlamydia Infections
HIV
DNA
Infection

Keywords

  • Adult
  • Chlamydia Infections/complications
  • Chlamydia trachomatis
  • Coinfection
  • Female
  • Humans
  • Middle Aged
  • Papanicolaou Test
  • Papillomaviridae
  • Papillomavirus Infections/complications
  • Uterine Cervical Neoplasms/complications
  • Young Adult

Cite this

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title = "HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality: baseline data of the HPV Pathogen ISS study",
abstract = "Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59{\%}) and 16 (10{\%}) women respectively, and 15 (9{\%}) of women were infected by both. Of the HPV positive samples, 89 (79{\%}) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.",
keywords = "Adult, Chlamydia Infections/complications, Chlamydia trachomatis, Coinfection, Female, Humans, Middle Aged, Papanicolaou Test, Papillomaviridae, Papillomavirus Infections/complications, Uterine Cervical Neoplasms/complications, Young Adult",
author = "Fabiola Mancini and Fenicia Vescio and Stefania Mochi and Luisa Accardi and {di Bonito}, Paola and Alessandra Ciervo",
year = "2018",
month = "6",
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language = "English",
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journal = "Infezioni in Medicina",
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}

TY - JOUR

T1 - HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality

T2 - baseline data of the HPV Pathogen ISS study

AU - Mancini, Fabiola

AU - Vescio, Fenicia

AU - Mochi, Stefania

AU - Accardi, Luisa

AU - di Bonito, Paola

AU - Ciervo, Alessandra

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.

AB - Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.

KW - Adult

KW - Chlamydia Infections/complications

KW - Chlamydia trachomatis

KW - Coinfection

KW - Female

KW - Humans

KW - Middle Aged

KW - Papanicolaou Test

KW - Papillomaviridae

KW - Papillomavirus Infections/complications

KW - Uterine Cervical Neoplasms/complications

KW - Young Adult

M3 - Article

VL - 26

SP - 139

EP - 144

JO - Infezioni in Medicina

JF - Infezioni in Medicina

SN - 1124-9390

IS - 2

ER -