HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality: baseline data of the HPV Pathogen ISS study

Research output: Contribution to journalArticle

Abstract

Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were detected in 97 (59%) and 16 (10%) women respectively, and 15 (9%) of women were infected by both. Of the HPV positive samples, 89 (79%) were HR-HPV types or probable HR types and HPV16 was the most represented genotype. Interestingly, it was observed that co-infection was more frequent than HPV infection alone in women with high grade lesions.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalLe infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
Volume26
Issue number2
Publication statusPublished - Jun 1 2018

Keywords

  • Adult
  • Chlamydia Infections/complications
  • Chlamydia trachomatis
  • Coinfection
  • Female
  • Humans
  • Middle Aged
  • Papanicolaou Test
  • Papillomaviridae
  • Papillomavirus Infections/complications
  • Uterine Cervical Neoplasms/complications
  • Young Adult

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