HPV-DNA testing for cervical cancer precursors: From evidence to clinical practice

Massimo Origoni, P. Cristoforoni, S. Costa, L. Mariani, P. Scirpa, A. Lorincz, M. Sideri

Research output: Contribution to journalArticle


The large amount of literature published over the last two decades on human papillomavirus (HPV)-DNA testing has definitely demonstrated the association between high-risk viral genotypes (hrHPV) and cervical cancer. Moreover, hrHPV-DNA testing has shown excellent performance in several clinical applications, from screening settings to the follow-up of treated patients, compared to conventional cytology or colposcopy options. On the other hand, when a huge number of reports are published on the same subject in a relatively short period of time, with many variations in settings, study designs and applications, the result is often confusion and decreased comprehension by readers. In daily office practice, several different situations (in symptomatic or asymptomatic women) can be positively managed by the correct use of hrHPV-DNA testing. Validated hrHPV-DNA testing and, specifically, the HC2® assay, due to its excellent sensitivity and negative predictive value together with optimal reproducibility, currently represent a powerful tool in the clinician's hands to optimally manage several situations related to HPV infection and the potential development of cervical cancer.

Original languageEnglish
Article number6
Issue number1
Publication statusPublished - Jun 18 2012


  • Cervical cancer
  • Human papillomavirus (HPV)
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'HPV-DNA testing for cervical cancer precursors: From evidence to clinical practice'. Together they form a unique fingerprint.

  • Cite this

    Origoni, M., Cristoforoni, P., Costa, S., Mariani, L., Scirpa, P., Lorincz, A., & Sideri, M. (2012). HPV-DNA testing for cervical cancer precursors: From evidence to clinical practice. ecancermedicalscience, 6(1), [6]. https://doi.org/10.3332/ecancer.2012.258