HPV, HIV infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers

M. Conti, A. Agarossi, F. Parazzini, M. L. Muggiasca, A. Boschini, E. Negri, E. Casolati

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The relation between human immunodeficiency virus (HIV), human papilloma virus (HPV) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (CIN) has been analyzed in a cross- sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the Colposcopic Unit of the Ospedale Luigi Sacco of Milan and women consecutively admitted to the Community for Past Drug Abusers, S. Patrignano, Rimini. A total of 434 subjects entered the study; of those 128 (30%) had a diagnosis of CIN. Compared with HIV-negative subjects, odds ratio (OR) of CIN was 8.0 (95% confidence interval (CI) 4.6- 14.1) for HIV-positive ones and the frequency of CIN 2 and 3 was higher in HIV-positive than that in HIV-negative subjects (χ2 1 trend, 6.67, P = 0.01). Compared with women without current HPV infection the OR estimate was 38.0 (95% CI 20.3-71.2) in those with current diagnosis of HPV infection. Considering HIV-positive subjects only, the frequency of CIN increased with stage of HIV infection and was higher in women with lower CD4+ values. Finally, no relation emerged between CIN risk and age, indicators of sexual habits, oral contraceptive use, parity, and history of spontaneous or induced abortions.

Original languageEnglish
Pages (from-to)344-348
Number of pages5
JournalGynecologic Oncology
Volume49
Issue number3
DOIs
Publication statusPublished - 1993

Fingerprint

Papillomaviridae
Cervical Intraepithelial Neoplasia
Virus Diseases
Drug Users
HIV
Habits
Odds Ratio
Confidence Intervals
Reproductive History
Induced Abortion
Spontaneous Abortion
Oral Contraceptives
Parity
Cross-Sectional Studies

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

HPV, HIV infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers. / Conti, M.; Agarossi, A.; Parazzini, F.; Muggiasca, M. L.; Boschini, A.; Negri, E.; Casolati, E.

In: Gynecologic Oncology, Vol. 49, No. 3, 1993, p. 344-348.

Research output: Contribution to journalArticle

Conti, M. ; Agarossi, A. ; Parazzini, F. ; Muggiasca, M. L. ; Boschini, A. ; Negri, E. ; Casolati, E. / HPV, HIV infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers. In: Gynecologic Oncology. 1993 ; Vol. 49, No. 3. pp. 344-348.
@article{a7314112ff674d72b8084675e00f7828,
title = "HPV, HIV infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers",
abstract = "The relation between human immunodeficiency virus (HIV), human papilloma virus (HPV) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (CIN) has been analyzed in a cross- sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the Colposcopic Unit of the Ospedale Luigi Sacco of Milan and women consecutively admitted to the Community for Past Drug Abusers, S. Patrignano, Rimini. A total of 434 subjects entered the study; of those 128 (30{\%}) had a diagnosis of CIN. Compared with HIV-negative subjects, odds ratio (OR) of CIN was 8.0 (95{\%} confidence interval (CI) 4.6- 14.1) for HIV-positive ones and the frequency of CIN 2 and 3 was higher in HIV-positive than that in HIV-negative subjects (χ2 1 trend, 6.67, P = 0.01). Compared with women without current HPV infection the OR estimate was 38.0 (95{\%} CI 20.3-71.2) in those with current diagnosis of HPV infection. Considering HIV-positive subjects only, the frequency of CIN increased with stage of HIV infection and was higher in women with lower CD4+ values. Finally, no relation emerged between CIN risk and age, indicators of sexual habits, oral contraceptive use, parity, and history of spontaneous or induced abortions.",
author = "M. Conti and A. Agarossi and F. Parazzini and Muggiasca, {M. L.} and A. Boschini and E. Negri and E. Casolati",
year = "1993",
doi = "10.1006/gyno.1993.1137",
language = "English",
volume = "49",
pages = "344--348",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - HPV, HIV infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers

AU - Conti, M.

AU - Agarossi, A.

AU - Parazzini, F.

AU - Muggiasca, M. L.

AU - Boschini, A.

AU - Negri, E.

AU - Casolati, E.

PY - 1993

Y1 - 1993

N2 - The relation between human immunodeficiency virus (HIV), human papilloma virus (HPV) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (CIN) has been analyzed in a cross- sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the Colposcopic Unit of the Ospedale Luigi Sacco of Milan and women consecutively admitted to the Community for Past Drug Abusers, S. Patrignano, Rimini. A total of 434 subjects entered the study; of those 128 (30%) had a diagnosis of CIN. Compared with HIV-negative subjects, odds ratio (OR) of CIN was 8.0 (95% confidence interval (CI) 4.6- 14.1) for HIV-positive ones and the frequency of CIN 2 and 3 was higher in HIV-positive than that in HIV-negative subjects (χ2 1 trend, 6.67, P = 0.01). Compared with women without current HPV infection the OR estimate was 38.0 (95% CI 20.3-71.2) in those with current diagnosis of HPV infection. Considering HIV-positive subjects only, the frequency of CIN increased with stage of HIV infection and was higher in women with lower CD4+ values. Finally, no relation emerged between CIN risk and age, indicators of sexual habits, oral contraceptive use, parity, and history of spontaneous or induced abortions.

AB - The relation between human immunodeficiency virus (HIV), human papilloma virus (HPV) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (CIN) has been analyzed in a cross- sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the Colposcopic Unit of the Ospedale Luigi Sacco of Milan and women consecutively admitted to the Community for Past Drug Abusers, S. Patrignano, Rimini. A total of 434 subjects entered the study; of those 128 (30%) had a diagnosis of CIN. Compared with HIV-negative subjects, odds ratio (OR) of CIN was 8.0 (95% confidence interval (CI) 4.6- 14.1) for HIV-positive ones and the frequency of CIN 2 and 3 was higher in HIV-positive than that in HIV-negative subjects (χ2 1 trend, 6.67, P = 0.01). Compared with women without current HPV infection the OR estimate was 38.0 (95% CI 20.3-71.2) in those with current diagnosis of HPV infection. Considering HIV-positive subjects only, the frequency of CIN increased with stage of HIV infection and was higher in women with lower CD4+ values. Finally, no relation emerged between CIN risk and age, indicators of sexual habits, oral contraceptive use, parity, and history of spontaneous or induced abortions.

UR - http://www.scopus.com/inward/record.url?scp=0027233411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027233411&partnerID=8YFLogxK

U2 - 10.1006/gyno.1993.1137

DO - 10.1006/gyno.1993.1137

M3 - Article

C2 - 8390961

AN - SCOPUS:0027233411

VL - 49

SP - 344

EP - 348

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -