HPV nel carcinoma dell’orofaringe: Le nozioni base da conoscere nella pratica clinica

Translated title of the contribution: HPV in oropharyngeal cancer: The basics to know in clinical practice

S. Elrefaey, M. A. Massaro, S. Chiocca, F. Chiesa, Mohssen Ansarin

Research output: Contribution to journalArticle


The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas in other subsites of the head and neck, in spite of the reduced prevalence of smoking. Human papilloma virus (HPV) infection, and in particular type 16 (HPV-16), is now recognized as a significant player in the onset of HPV positive OPSCC, with different epidemiological, clinical, anatomical, radiological, behavioural, biological and prognostic characteristics from HPV negative OPSCC. Indeed, the only subsite in the head and neck with a demonstrated aetiological viral link is, at present, the oropharynx. These observations lead to questions regarding management choices for patients based on tumour HPV status with important consequences on treatment, and on the role of vaccines and targeted therapy over the upcoming years.

Original languageItalian
Pages (from-to)299-309
Number of pages11
JournalActa Otorhinolaryngologica Italica
Issue number5
Publication statusPublished - Oct 1 2014


ASJC Scopus subject areas

  • Otorhinolaryngology

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